| Gene Symbol |
DOCK3
|
| Entrez Gene |
1795
|
| Alt Symbol |
MOCA, PBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dedicator of cytokinesis 3
|
| Other Description |
dedicator of cytokinesis protein 3|modifier of cell adhesion|presenilin-binding protein
|
| Swissprots |
Q8IZD9 O15017
|
| Accessions |
CCQ43290 EAW65134 EAW65135 EAW65136 EAW65137 Q8IZD9 AB002297 BAA20759 AK310984 AY145303 AAN12301 AY254099 AAP80572 BC037933 BC045793 BC131746 AAI31747 BC156339 AAI56340 BC157127 AAI57128 XM_005264914 XP_005264971 XM_005264915 XP_005264972 XM_005264916 XP_005264973 XM_005264917 XP_005264974 XM_005264918 XP_005264975 XM_006713008 XP_006713071 XM_006713009 XP_006713072 XM_006713010 XP_006713073 XM_011533441 XP_011531743 XM_011533442 XP_011531744 XM_011533443 XP_011531745 XM_011533444 XP_011531746 XM_011533445 XP_011531747 XM_011533446 XP_011531748 NM_004947 NP_004938
|
| Function |
Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. {ECO:0000269|PubMed:11696419}.
|