DOCK3

Gene Symbol	DOCK3
Entrez Gene	1795
Alt Symbol	MOCA, PBP
Species	Human
Gene Type	protein-coding
Description	dedicator of cytokinesis 3
Other Description	dedicator of cytokinesis protein 3|modifier of cell adhesion|presenilin-binding protein
Swissprots	Q8IZD9 O15017
Accessions	CCQ43290 EAW65134 EAW65135 EAW65136 EAW65137 Q8IZD9 AB002297 BAA20759 AK310984 AY145303 AAN12301 AY254099 AAP80572 BC037933 BC045793 BC131746 AAI31747 BC156339 AAI56340 BC157127 AAI57128 XM_005264914 XP_005264971 XM_005264915 XP_005264972 XM_005264916 XP_005264973 XM_005264917 XP_005264974 XM_005264918 XP_005264975 XM_006713008 XP_006713071 XM_006713009 XP_006713072 XM_006713010 XP_006713073 XM_011533441 XP_011531743 XM_011533442 XP_011531744 XM_011533443 XP_011531745 XM_011533444 XP_011531746 XM_011533445 XP_011531747 XM_011533446 XP_011531748 NM_004947 NP_004938
Function	Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stimulate Tau/MAPT phosphorylation suggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, suggesting that it may affect the function of some small GTPase involved in the regulation of actin cytoskeleton or cell adhesion receptors (By similarity). {ECO:0000250}.
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	In normal brains, it is localized in the neuropil, and occasionally in the pyramidal cells, while in Alzheimer disease brains, it is associated with neurofibrillary tangles. {ECO:0000269|PubMed:11696419}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DOCK3 ELISA Kit (Sandwich ELISA) - LS-F7541 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.053 ng/ml Range 0.156-10 ng/ml

Human DOCK3 ELISA Kit - abx151335 from Abbexa Category ELISA Kit Sensitivity 0.053 ng/ml Range 0.156 ng/ml - 10 ng/ml

Dedicator Of Cytokinesis 3 (DOCK3), Human, ELISA Kit - SEG183Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.053ng/mL Range 0.156-10ng/mL

dedicator of cytokinesis 3, ELISA Kit - MBS9319084 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Dedicator Of Cytokinesis 3 (DOCK3), ELISA Kit - MBS2020174 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.053ng/mL. Range 0.156-10ng/mL

ELISA Kit for Dedicator Of Cytokinesis 3 (DOCK3) - SEG183Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Dedicator Of Cytokinesis 3 (DOCK3) - SEG183Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.053ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Human Dedicator Of Cytokinesis 3 (DOCK3) ELISA Kit - EKU03645 from Biomatik Category ELISA Kit Prices $735.00, $3,234.00, $5,880.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.053 ng/mL Range 0.156-10 ng/mL

Dedicator Of Cytokinesis 3 (DOCK3), Human, ELISA Kit - DL-DOCK3-Hu from ARP American Research Products Category ELISA Kit Prices $655.00 Sizes 96 t Range 0.156-10 ng/mL

Human DOCK3 ELISA Kit - abx571128 from Abbexa Category ELISA Kit Sensitivity 0.053 ng/ml Range 0.156 ng/ml - 10 ng/ml

Human DOCK3 ELISA Kit - E011466 from Biobool Category ELISA Kit Sensitivity Typically less than 0.053ng/mL.

DOCK3 ELISA Kit (Human) (OKDD00237) - OKDD00237 from Aviva Systems Biology Category ELISA Kit Prices $580.00 Sizes 96 wells Sensitivity < 0.053 ng/mL Range 0.156-10 ng/mL

Human Dedicator of cytokinesis protein 3 (DOCK3) ELISA Kit - AE46812HU from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.053 ng/mL Range 0.156-10 ng/mL

Dedicator Of Cytokinesis 3 (DOCK3), ELISA Kit - MBS451295 from MyBioSource Category ELISA Kit Prices $415.00, $550.00, $2,425.00, $4,710.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.053ng/mL Range 0.156-10ng/mL

Dedicator of Cytokinesis 3 (DOCK3), ELISA Kit - MBS9372651 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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