| Gene Symbol |
TRIP4
|
| Entrez Gene |
9325
|
| Alt Symbol |
ASC-1, ASC1, HsT17391, ZC2HC5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thyroid hormone receptor interactor 4
|
| Other Description |
TR-interacting protein 4|TRIP-4|activating signal cointegrator 1|thyroid receptor interacting protein 4|thyroid receptor-interacting protein 4|zinc finger, C2HC5-type
|
| Swissprots |
Q9UKH0 B2RAS0 Q15650 Q96ED7
|
| Accessions |
EAW77684 EAW77685 Q15650 AK000433 AK314319 BAG36967 BC012448 AAH12448 BG166305 BQ225927 CA425850 EU446746 ABZ92275 L40371 AAC41738 XM_005254789 XP_005254846 XR_243130 NM_016213 NP_057297
|
| Function |
Transcription coactivator which associates with nuclear receptors, transcriptional coactivators including EP300, CREBBP and NCOA1, and basal transcription factors like TBP and TFIIA to facilitate nuclear receptors-mediated transcription. May thereby play an important role in establishing distinct coactivator complexes under different cellular conditions. Plays a role in thyroid hormone receptor and estrogen receptor transactivation (PubMed:10454579, PubMed:25219498). Also involved in androgen receptor transactivation (By similarity). Plays a pivotal role in the transactivation of NF-kappa-B, SRF and AP1. Acts as a mediator of transrepression between nuclear receptor and either AP1 or NF- kappa-B (PubMed:12077347). {ECO:0000250|UniProtKB:Q9QXN3, ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:12077347, ECO:0000269|PubMed:25219498}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytosol {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000269|PubMed:20873783}. Note=Cytoplasmic under conditions of serum deprivation (PubMed:10454579). Colocalizes with NEK6 in the centrosome (PubMed:20873783). {ECO:0000269|PubMed:10454579, ECO:0000269|PubMed:20873783}.
|