| Gene Symbol |
SKA1
|
| Entrez Gene |
220134
|
| Alt Symbol |
C18orf24
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
spindle and kinetochore associated complex subunit 1
|
| Other Description |
spindle and KT (kinetochore) associated 1|spindle and kinetochore-associated protein 1
|
| Swissprots |
B4E0P4 B2R9Y6 Q96BD8
|
| Accessions |
EAW62971 EAW62972 EAW62973 Q96BD8 AK303464 BAG64506 AK313968 BAG36683 BC005972 BC015606 BC015706 AAH15706 BG493245 BM470268 BQ069178 BU659790 BX956145 CN403719 NM_001039535 NP_001034624 NM_145060 NP_659497
|
| Function |
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint. The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies. The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner. In the complex, it mediates the interaction with microtubules. {ECO:0000269|PubMed:17093495, ECO:0000269|PubMed:19289083}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton, spindle. Chromosome, centromere, kinetochore. Note=Localizes to the outer kinetochore and spindle microtubules during mitosis in a NDC80 complex-dependent manner. Localizes to both the mitotic spindle and kinetochore-associated proteins. Associates with kinetochores following microtubule attachment from prometaphase, through mid- anaphase and then vanishes in telophase.
|