CHMP6

Gene Symbol	CHMP6
Entrez Gene	79643
Alt Symbol	VPS20
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 6
Other Description	chromatin modifying protein 6\|chromatin-modifying protein 6\|hVps20\|vacuolar protein sorting-associated protein 20
Swissprots	A8K7U0 Q96FZ7 Q53FU4 Q9HAE8
Accessions	EAW89622 Q96FZ7 AK021811 BAB13901 AK223187 BAD96907 AK292105 BAF84794 AY329087 AAQ91196 BC010108 AAH10108 BP196406 CR457284 CAG33565 HQ448670 ADQ33148 XM_005257668 XP_005257725 NM_024591 NP_078867
Function	Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities,
Subcellular Location	Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane {ECO:0000305}. Note=Localizes to endosomal membranes.
Tissue Specificity	Ubiquitously expressed. {ECO:0000269\|PubMed:15511219}.
Top Pathways	Endocytosis

CHMP6 (B-3) - sc-398963 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Mouse
Clonality	Monoclonal

CHMP6 (B-3): sc-398963. Western blot analysis of CHMP6 expression in non-transfected 293T: sc-117752 (A), human CHMP6 transfected 293T: sc-371845 (B), MCF7 (C), JEG-3 (D) and Hep G2 (E) whole cell lysates.

CHMP6 (FL-201) - sc-67231 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

CHMP6 (FL-201): sc-67231. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of exocrine glandular cells and Islets of Langerhans.

CHMP6 (K-13) - sc-49922 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-CHMP6 antibody - ab76929 from Abcam

Prices	$370.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

All lanes : Anti-CHMP6 antibody (ab76929) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Whole Cell Lysate Lane 2 : Jurkat (Human T cell lymphoblast-like cell line) Whole Cell Lysate Lane 3 : HepG2 (Human hepatocellular liver carcinoma cell line) Whole Cell LysateLane 4 : HEK293 (Human embryonic kidney cell line) Whole Cell LysateLane 5 : MCF7 (Human breast adenocarcinoma cell line) Whole Cell LysateLane 6 : JEG-3 (Human placental choriocarcinoma cell line) Whole Cell Lysate Lane 7 : K562 (Human erythromyeloblastoid leukemia cell line) Whole Cell LysateLysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-CHMP6 antibody - ab133943 from Abcam

Prices	$370.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 antibody (ab133943) at 1 µg/ml + HepG2 cell lysate at 10 µg

Anti-CHMP6 Antibody (C-Terminus) - LS-C94079 from LifeSpan Bioscience

Prices	$325.00
Sizes	500 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (C-Terminus) - LS-C94084 from LifeSpan Bioscience

Prices	$325.00
Sizes	500 µg
Host	Sheep
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa1-30, AP) - LS-C233807 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa1-30, Biotin) - LS-C233810 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa1-30, APC) - LS-C233809 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa1-30, PE) - LS-C233812 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa1-30, FITC) - LS-C233811 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa100-149) - LS-C152002 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa1-30, Azide-free, HRP) - LS-C249669 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (aa1-30) - LS-C320363 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-CHMP6 Antibody (N-Terminus) - LS-C345317 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of CHMP6 Antibody with human Jurkat Whole Cell lysate.

Anti-CHMP6 Antibody (aa1-30) - LS-C168741 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Western blot of lysate from human spleen tissue lysate, using CHMP6 Antibody. Antibody was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L (HRP) at 1:5000 dilution was used as the secondary antibody. Lysate at 35ug per lane.

CHMP6 Antibody - NBP1-83727 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CHMP6 Antibody - NBP1-83726 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CHMP6 Antibody [NBP1-83726] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

CHMP6 Antibody - NBP2-15889 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: CHMP6 Antibody [NBP2-15889] - Sample (30 ug of whole cell lysate) A: Raji 12% SDS PAGE gel, diluted at 1:1000.

Anti-CHMP6 antibody produced in rabbit - SAB2701297 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-CHMP6: <B>Cat. No. SAB2701297</B>: Western Blot analysis of CHMP6 in extracts from <B>Lanes</B><BR/>A. Raji using <B>Cat. No. SAB2701297</B> at a 1:1000 dilution.

Anti-CHMP6 antibody produced in rabbit - HPA024460 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-CHMP6: <B>Cat. No. HPA024460</B>: Immunohistochemical staining of human parathyroid gland shows strong membranous positivity in glandular cells.

Anti-CHMP6 antibody produced in rabbit - HPA023001 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-CHMP6: <B>Cat. No. HPA023001</B>: Immunohistochemical staining of human testis shows distinct cytoplasmic positivity in cells of ductus seminiferus.

CHMP6 Antibody - middle region (ARP65538_P050) - ARP65538_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

CHMP6 Antibody - N-terminal region (ARP73789_P050) - ARP73789_P050 from Aviva Systems Biology

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

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