| Gene Symbol | CHMP6 |
|---|---|
| Entrez Gene | 79643 |
| Alt Symbol | VPS20 |
| Species | Human |
| Gene Type | protein-coding |
| Description | charged multivesicular body protein 6 |
| Other Description | chromatin modifying protein 6|chromatin-modifying protein 6|hVps20|vacuolar protein sorting-associated protein 20 |
| Swissprots | A8K7U0 Q96FZ7 Q53FU4 Q9HAE8 |
| Accessions | EAW89622 Q96FZ7 AK021811 BAB13901 AK223187 BAD96907 AK292105 BAF84794 AY329087 AAQ91196 BC010108 AAH10108 BP196406 CR457284 CAG33565 HQ448670 ADQ33148 XM_005257668 XP_005257725 NM_024591 NP_078867 |
| Function | Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, |
| Subcellular Location | Endomembrane system. Endosome membrane; Lipid-anchor. Late endosome membrane {ECO:0000305}. Note=Localizes to endosomal membranes. |
| Tissue Specificity | Ubiquitously expressed. {ECO:0000269|PubMed:15511219}. |
| Top Pathways | Endocytosis |
CHMP6 CRISPR/Cas9 KO Plasmid (h) - sc-406179 from Santa Cruz Biotechnology
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CHMP6 HDR Plasmid (h) - sc-406179-HDR from Santa Cruz Biotechnology
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CHMP6 Double Nickase Plasmid (h) - sc-406179-NIC from Santa Cruz Biotechnology
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CHMP6 Double Nickase Plasmid (h2) - sc-406179-NIC-2 from Santa Cruz Biotechnology
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CHMP6 CRISPR Activation Plasmid (h) - sc-406179-ACT from Santa Cruz Biotechnology
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CHMP6 CRISPR Activation Plasmid (h2) - sc-406179-ACT-2 from Santa Cruz Biotechnology
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CHMP6 Lentiviral Activation Particles (h) - sc-406179-LAC from Santa Cruz Biotechnology
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CHMP6 Lentiviral Activation Particles (h2) - sc-406179-LAC-2 from Santa Cruz Biotechnology
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CHMP6 siRNA (h) - sc-60376 from Santa Cruz Biotechnology
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CHMP6 shRNA Plasmid (h) - sc-60376-SH from Santa Cruz Biotechnology
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CHMP6 shRNA (h) Lentiviral Particles - sc-60376-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU144401 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6076 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6076 from Sigma-Aldrich
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CHMP6 siRNA (Human) - CRJ2450 from Cohesion Biosciences
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CHMP6 - MBS8238443 from MyBioSource
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CHMP6 CRISPR/Cas9 KO Plasmid (h2) - sc-406179-KO-2 from Santa Cruz Biotechnology
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CHMP6 HDR Plasmid (h2) - sc-406179-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human CHMP6 (NM_024591.4) - SHH263253 from Creative biogene
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Human CHMP6 siRNA - orb272951 from Biorbyt
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CHMP6 shRNA Plasmid (Human) - CHJ2450 from Cohesion Biosciences
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CHMP6 miRNA 3'UTR clone - MiUTR3H-11541 from Creative biogene
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