CCAR2

Gene Symbol	CCAR2
Entrez Gene	57805
Alt Symbol	DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC
Species	Human
Gene Type	protein-coding
Description	cell cycle and apoptosis regulator 2
Other Description	cell cycle and apoptosis regulator protein 2|cell division cycle and apoptosis regulator protein 2|deleted in breast cancer 1|p30 DBC protein
Swissprots	Q8N3G7 Q6P0Q9 Q8N8M1 B2RB79 A6NL03 Q8N163 Q9HD12 D3DSR6 Q9NT55 Q9H9Q9 Q8TF34
Accessions	CBW53721 CBX74356 EAW63658 EAW63659 EAW63660 EAW63661 EAW63662 Q8N163 AB075847 BAB85553 AF293335 AAG02472 AK022661 BAB14163 AK095712 BAG53111 AK096547 AK314535 BAG37126 AL137523 CAB70788 AL834162 CAD38866 AL834351 CAD39016 AL834352 CAD39017 AM392706 CAL37584 AM393823 CAL38698 BC003172 BC018269 AAH18269 BC065495 AAH65495 BI561261 BX390251 BX640952 CAE45976 DA110888 DA721640 XM_011544603 XP_011542905 XM_011544604 XP_011542906 NM_199205 NM_021174 NP_066997 NR_033902
Function	Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by prevent
Subcellular Location	Nucleus {ECO:0000269|PubMed:23352644}. Note=Recruited to chromatin, post-UV irradiation.
Tissue Specificity	Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. {ECO:0000269|PubMed:12370419}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human KIAA1967 full length protein - ab132976 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human DBC1/p30 Protein - H00057805-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

DBC1/p30 Recombinant Protein - P5177 from Novus Biologicals Category Protein Prices $449.00 Sizes 500 µg Species Protozoa

KIAA1967-Antibody-N-term-Blocking-Peptide - BP16400a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

KIAA1967 - H00057805-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

KIAA1967 - H00057805-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

DBC1 fusion protein - ag18557 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

DBC1 fusion protein - ag18374 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human KIAA1967, His-tagged - KIAA1967-3705H from Creative Biomart Category Protein Source E. coli Species Human

KIAA1967 Blocking Peptide - CBP3427 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

DBC-1 (Q455) Peptide - BS2331P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human DBIRD complex subunit KIAA1967(KIAA1967) ,partial - CSB-YP822681HU CSB-EP822681HU CSB-BP822681HU CSB-MP822681HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

KIAA1967 (transcript variant 1) - TP320900 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

CCAR2/DBC1, Peptide - MBS428375 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg

KIAA1967 Blocking Peptide - abx162289 from Abbexa Category Peptide Species Human

KIAA1967 Peptide, Human - M34GP08164H from Creative Peptides Category Peptide Source Synthetic. Species Human

DBIRD complex subunit KIAA1967 (KIAA1967), partial, Recombinant Protein - MBS1364856 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

KIAA1967 Peptide - orb224313 from Biorbyt Category Peptide Species Human

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