CCAR2

Gene Symbol CCAR2
Entrez Gene 57805
Alt Symbol DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC
Species Human
Gene Type protein-coding
Description cell cycle and apoptosis regulator 2
Other Description cell cycle and apoptosis regulator protein 2|cell division cycle and apoptosis regulator protein 2|deleted in breast cancer 1|p30 DBC protein
Swissprots Q8N3G7 Q6P0Q9 Q8N8M1 B2RB79 A6NL03 Q8N163 Q9HD12 D3DSR6 Q9NT55 Q9H9Q9 Q8TF34
Accessions CBW53721 CBX74356 EAW63658 EAW63659 EAW63660 EAW63661 EAW63662 Q8N163 AB075847 BAB85553 AF293335 AAG02472 AK022661 BAB14163 AK095712 BAG53111 AK096547 AK314535 BAG37126 AL137523 CAB70788 AL834162 CAD38866 AL834351 CAD39016 AL834352 CAD39017 AM392706 CAL37584 AM393823 CAL38698 BC003172 BC018269 AAH18269 BC065495 AAH65495 BI561261 BX390251 BX640952 CAE45976 DA110888 DA721640 XM_011544603 XP_011542905 XM_011544604 XP_011542906 NM_199205 NM_021174 NP_066997 NR_033902
Function Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by prevent
Subcellular Location Nucleus {ECO:0000269|PubMed:23352644}. Note=Recruited to chromatin, post-UV irradiation.
Tissue Specificity Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. {ECO:0000269|PubMed:12370419}.

Phospho-DBC1 (Thr454) Antibody - 4880 from Cell Signaling Technology

Prices $287.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293 and HeLa cell lines, untreated or UV-treated (100 J/m 2 and 4 hour recovery), using Phospho-DBC1 (Thr454) Antibody (upper) or β-actin Antibody #4967 (lower).

DBC1 (3G4) Mouse mAb - 5857 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Mouse
Clonality Monoclonal
Clone 3G4
Western blot analysis of extracts from various cell lines using DBC1 (3G4) Mouse mAb.

DBC1 Antibody - 5693 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using DBC1 Antibody.

DBC-1 (T-19) - sc-54067 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DBC-1 (T-19): sc-54067. Western blot analysis of DBC-1 expression in A549 (A), T-47D (B) and HeLa (C) whole cell lysates and A549 nuclear extract (D).

DBC-1 (H-120) - sc-67373 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
DBC-1 (H-120): sc-67373. Western blot analysis of DBC-1 expression in Jurkat nuclear extract.

DBC-1 (H-2) - sc-166733 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DBC-1 (H-2): sc-166733. Western blot analysis of DBC-1 expression in A549 nuclear extract (A) and T-47D whole cell lysate (B).

Anti-KIAA1967 antibody - ab167195 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-KIAA1967 antibody (ab167195) at 1 µg/ml + Jurkat cell lysate at 50 µgSecondaryGoat anti-mouse HRP conjugated antibody at 1/2500 dilution

Anti-KIAA1967 antibody - ab69562 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KIAA1967 antibody (ab69562) at 1/500 dilutionLane 1 : Jurkat cells extractsLane 2 : Jurkat cells extracts with immunizing peptide at 10 µgLysates/proteins at 30 µg per lane.

Anti-KIAA1967 antibody - ab57608 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-KIAA1967 antibody (ab57608) at 1 µg + A549 cell lysate at 25 µg

Anti-CCAR2 / KIAA1967 Antibody (aa650-700) - LS-C64523 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCAR2 / KIAA1967 Antibody (aa650-700) - LS-C287324 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CCAR2 / KIAA1967 Antibody (aa431-480) - LS-C119141 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from Jurkat cells, using KIAA1967 Antibody. The lane on the right is treated with the synthesized peptide.

Anti-CCAR2 / KIAA1967 Antibody - LS-C308635 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-CCAR2 / KIAA1967 Antibody - LS-C308637 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-CCAR2 / KIAA1967 Antibody - LS-C311318 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-CCAR2 / KIAA1967 Antibody (aa1-50) - LS-C287323 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human and Mouse DBC1/p30 DBC by Immunohistochemistry. Sample: FFPE sections of human ovarian carcinoma (left) and mouse teratoma (right). Antibody: Affinity purified rabbit anti-DBC1/p30 DBC used at a dilution of 1:5000 (0.2 ug/ml) and 1:1000 (1 ug/ml). Detection: DAB.

Anti-CCAR2 / KIAA1967 Antibody (aa5-366, Azide-free) - LS-C330402 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-CCAR2 / KIAA1967 Antibody (aa1-50) - LS-C286403 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Mouse DBC1/p30 by Immunohistochemistry. Sample: FFPE section of mouse squamous cell carcinoma Antibody: Affinity purified rabbit anti-DBC1/p30 used at a dilution of 1:250.

Anti-CCAR2 / KIAA1967 Antibody (N-Terminus) - LS-C178310 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
The lack of description.

Anti-CCAR2 / KIAA1967 Antibody (aa873-923) - LS-C290589 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Goat
Clonality Polyclonal
Detection of Mouse DBC1/p30 by Western Blot. Samples: Whole cell lysate (50 ug) from NIH3T3 , Renca, and TCMK-1 cells. Antibodies: Affinity purified goat anti-DBC1/p30 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Anti-CCAR2 / KIAA1967 Antibody (C-Terminus) - LS-C287326 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human DBC1/p30 DBC by Immunohistochemistry. Sample: FFPE section of human lung carcinoma. Antibody: Affinity purified rabbit anti-DBC1/p30 DBC used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-CCAR2 / KIAA1967 Antibody - LS-C346240 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence blot of U20S cell using CCAR2 antibody. Blue: DAPI for nuclear staining.

DBC1/p30 Antibody - NBP2-22294 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Goat
Clonality Polyclonal

DBC1/p30 Antibody - H00057805-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: DBC1/p30 Antibody [H00057805-B01P] - Analysis of KIAA1967 expression in Jurkat.

DBC1/p30 Antibody (4E6) - H00057805-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4E6
Western Blot: DBC1/p30 Antibody (4E6) [H00057805-M04] - Analysis of KIAA1967 expression in A-549 (Cat # L025V1).
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