CCAR2
| Gene Symbol | CCAR2 |
|---|---|
| Entrez Gene | 57805 |
| Alt Symbol | DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell cycle and apoptosis regulator 2 |
| Other Description | cell cycle and apoptosis regulator protein 2|cell division cycle and apoptosis regulator protein 2|deleted in breast cancer 1|p30 DBC protein |
| Swissprots | Q8N3G7 Q6P0Q9 Q8N8M1 B2RB79 A6NL03 Q8N163 Q9HD12 D3DSR6 Q9NT55 Q9H9Q9 Q8TF34 |
| Accessions | CBW53721 CBX74356 EAW63658 EAW63659 EAW63660 EAW63661 EAW63662 Q8N163 AB075847 BAB85553 AF293335 AAG02472 AK022661 BAB14163 AK095712 BAG53111 AK096547 AK314535 BAG37126 AL137523 CAB70788 AL834162 CAD38866 AL834351 CAD39016 AL834352 CAD39017 AM392706 CAL37584 AM393823 CAL38698 BC003172 BC018269 AAH18269 BC065495 AAH65495 BI561261 BX390251 BX640952 CAE45976 DA110888 DA721640 XM_011544603 XP_011542905 XM_011544604 XP_011542906 NM_199205 NM_021174 NP_066997 NR_033902 |
| Function | Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity. As part of a histone H3- specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors. Plays a critical role in maintaining genomic stability and cellular integrity following UV-induced genotoxic stress. Regulates the circadian expression of the core clock components NR1D1 and ARNTL/BMAL1. Enhances the transcriptional repressor activity of NR1D1 through stabilization of NR1D1 protein levels by prevent |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:23352644}. Note=Recruited to chromatin, post-UV irradiation. |
| Tissue Specificity | Expressed ubiquitously in normal tissues. Expressed in 84 to 100% of neoplastic breast, lung, and colon tissues. {ECO:0000269|PubMed:12370419}. |
DBC-1 CRISPR/Cas9 KO Plasmid (h) - sc-403056 from Santa Cruz Biotechnology
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DBC-1 HDR Plasmid (h) - sc-403056-HDR from Santa Cruz Biotechnology
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DBC-1 Double Nickase Plasmid (h) - sc-403056-NIC from Santa Cruz Biotechnology
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DBC-1 Double Nickase Plasmid (h2) - sc-403056-NIC-2 from Santa Cruz Biotechnology
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DBC-1 CRISPR Activation Plasmid (h) - sc-403056-ACT from Santa Cruz Biotechnology
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DBC-1 CRISPR Activation Plasmid (h2) - sc-403056-ACT-2 from Santa Cruz Biotechnology
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DBC-1 Lentiviral Activation Particles (h) - sc-403056-LAC from Santa Cruz Biotechnology
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DBC-1 Lentiviral Activation Particles (h2) - sc-403056-LAC-2 from Santa Cruz Biotechnology
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DBC-1 siRNA (h) - sc-72274 from Santa Cruz Biotechnology
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DBC-1 shRNA Plasmid (h) - sc-72274-SH from Santa Cruz Biotechnology
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DBC-1 shRNA (h) Lentiviral Particles - sc-72274-V from Santa Cruz Biotechnology
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DBC1/p30 RNAi - H00057805-R02 from Novus Biologicals
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MISSION® esiRNA - EHU160701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11165 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11165 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06374 from Sigma-Aldrich
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CCAR2 siRNA (Human) - CRJ1681 from Cohesion Biosciences
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DBC1/p30 RNAi - H00057805-R01 from Novus Biologicals
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CCAR2 - MBS8213707 from MyBioSource
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shRNA set against Human KIAA1967 (NM_021174.5) - SHH324915 from Creative biogene
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Human CCAR2 siRNA - orb272182 from Biorbyt
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CCAR2 shRNA Plasmid (Human) - CHJ1681 from Cohesion Biosciences
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KIAA1967 miRNA 3'UTR clone - MiUTR3H-09172 from Creative biogene
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