NCOA6

Gene Symbol NCOA6
Entrez Gene 23054
Alt Symbol AIB3, ASC2, NRC, PRIP, RAP250, TRBP
Species Human
Gene Type protein-coding
Description nuclear receptor coactivator 6
Other Description NRC RAP250|PPAR-interacting protein|activating signal cointegrator 2|activating signal cointegrator-2|amplified in breast cancer protein 3|amplified in breast cancer-3 protein|cancer-amplified transcriptional coactivator ASC-2|nuclear receptor coactivator RAP250|nuclear receptor-activating protein, 250 kDa|peroxisome proliferator-activated receptor interacting protein|peroxisome proliferator-activated receptor-interacting protein|thyroid hormone receptor binding protein|thyroid hormone receptor-binding protein
Swissprots Q9NTZ9 Q14686 E1P5P7 A6NLF1 Q9UH74 B2RMN5 Q9UK86
Accessions EAW76254 EAW76255 Q14686 AF128458 AAF37003 AF171667 AAF71829 AF177388 AAF13595 AF208227 AAF16403 AF245115 AAF78480 AI498955 AK027040 BC035676 BC047886 BC069829 BC114613 AAI14614 BC136272 AAI36273 BU187688 D80003 BAA11498 JF707637 AEG79564 JF707638 AEG79565 JF707639 AEG79566 L37706 XM_006723755 XP_006723818 XM_011528721 XP_011527023 XM_011528722 XP_011527024 XM_011528723 XP_011527025 XM_011528724 XP_011527026 XM_011528725 XP_011527027 XM_011528726 XP_011527028 XM_011528727 XP_011527029 XM_011528728 XP_011527030 XM_011528729 XP_011527031 XM_011528730 XP_011527032 XM_011528731 XP_011527033 XM_011528732 XP_011527034 XM_011528733 XP_011527035 XM_011528734 XP_011527036 XM_011528735 XP_011527037 XR_936514 XR_936515 NM_001242539 NP_001229468 NM_014071 NP_054790
Function Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
Subcellular Location Nucleus.
Tissue Specificity Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.

PRIP (S-20) - sc-49088 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PRIP (C-20) - sc-49086 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PRIP (39-Q) - sc-101129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
PRIP (39-Q): sc-101129. Western blot analysis of PRIP expression in HeLa nuclear extract.

Anti-ASC-2 antibody - ab84099 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ASC-2 by Immunohistochemistry.Sample: FFPE section of Human breast adenocarcinoma.Antibody: ab84099 used at a dilution of 1/100.Detection: DAB.

Anti-ASC-2 antibody - ab18193 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ASC-2 antibody (ab18193) at 1 µg/mlLane 1 : HeLa (Human epithelial carcinoma cell line) Nuclear LysateLane 2 : HepG2 (Human hepatocellular liver carcinoma cell line) Nuclear LysateLane 3 : MCF7 (Human breast adenocarcinoma cell line) Nuclear LysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-ASC-2 antibody - ab56972 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-NCOA6 / ASC-2 Antibody (C-Terminus) - LS-C286295 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ASC2 by Immunohistochemistry. Sample: FFPE section of human stomach adenocarcinoma. Antibody: Affinity purified rabbit anti-ASC2 used at a dilution of 1:100. Detection: DAB.

Anti-NCOA6 / ASC-2 Antibody (C-Terminus) - LS-C287302 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ASC2 by Immunohistochemistry. Sample: FFPE section of human stomach carcinoma. Antibody: Affinity purified rabbit anti-ASC2 used at a dilution of 1:1000 (1 ug/ml).

Anti-NCOA6 / ASC-2 Antibody (aa1050-1100) - LS-C287301 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human ASC2 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-ASC2 used at a dilution of 1:1000 (1 ug/ml).

Anti-NCOA6 / ASC-2 Antibody (C-Terminus) - LS-C69307 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-NCOA6 / ASC-2 Antibody (aa1050-1100) - LS-C69306 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ASC2 Antibody - NB100-56076 from Novus Biologicals

Prices $129.00, $229.00
Sizes 25 µl, 50 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ASC2 Antibody [NB100-56076] - analysis of ASC2/POP1 using this antibody. HEK-293 cells were transiently transfected with plasmids encoding ASC2, POP1 or a negative control plasmid. ASC2 and POP1 were detected at the expected 12 kDa molecular weight.

NCOA6 Antibody - NB200-335 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NCOA6 Antibody [NB200-335] - Detection of Human ASC2 by Western Blot. Samples: Whole cell lysate (5, 15 and 50 ug) from HeLa cells prepared using NETN lysis buffer. Antibody: Affinity purified rabbit anti-ASC2 antibody NB200-335 used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

NCOA6 Antibody - NB200-336 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunoprecipitation: NCOA6 Antibody [NB200-336] - Detection of Human ASC2 by Western Blot of Immunoprecipitates

NCOA6 Antibody - NBP1-89193 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: NCOA6 Antibody [NBP1-89193] - Lane 1: Marker [kDa] 250, 130, 100, 70, 55, 35, 25, 15, 10. Lane 2: HELA

NCOA6 Antibody (2D7) - H00023054-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D7
Western Blot: NCOA6 Antibody (2D7) [H00023054-M01] - NCOA6 monoclonal antibody (M01), clone 2D7 Analysis of NCOA6 expression in Hela S3 NE.

NCOA6 Antibody - H00023054-A01 from Novus Biologicals

Prices $269.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Monoclonal Anti-NCOA6 antibody produced in mouse - WH0023054M1 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D7
<B>Immunoblotting</B><BR/>Monoclonal Anti-NCOA6, <B>Cat. No. WH0023054M1</B> used at the antibody concentration: 1 ~ 5 μg/mL. Specific band of ~219.1 kDa using Hela NE lysate.

Monoclonal Anti-ASC-2 antibody produced in mouse - A5355 from Sigma-Aldrich

Prices $465.00
Sizes 200 µl
Host Mouse
Clonality Monoclonal
Clone A3C1

Anti-NCOA6 antibody produced in rabbit - HPA004198 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-NCOA6: <B>Cat. No. HPA004198</B>: Immunoperoxidase staining of formalin-fixed, paraffin-embedded human duodenal tissue showing nuclear staining of glandular cells.

NCOA6-Antibody-monoclonal-M01 - AT2985a from Abgent, a WuXi AppTec company

Prices $315.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2D7
Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunogen (37.84 KDa) .

NCOA-6 antibody - 25241-1-AP from Acris Antibodies

Prices $270.00
Sizes 150 µl
Host Rabbit
Clonality Polyclonal
Mouse liver tissue were subjected to SDS PAGE followed by western blot with 25241-1-AP( NCOA6 Antibody) at dilution of 1:600

NCOA-6 antibody - H00023054-A01 from Acris Antibodies

Prices $300.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
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