| Gene Symbol |
NCOA6
|
| Entrez Gene |
23054
|
| Alt Symbol |
AIB3, ASC2, NRC, PRIP, RAP250, TRBP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor coactivator 6
|
| Other Description |
NRC RAP250|PPAR-interacting protein|activating signal cointegrator 2|activating signal cointegrator-2|amplified in breast cancer protein 3|amplified in breast cancer-3 protein|cancer-amplified transcriptional coactivator ASC-2|nuclear receptor coactivator RAP250|nuclear receptor-activating protein, 250 kDa|peroxisome proliferator-activated receptor interacting protein|peroxisome proliferator-activated receptor-interacting protein|thyroid hormone receptor binding protein|thyroid hormone receptor-binding protein
|
| Swissprots |
Q9NTZ9 Q14686 E1P5P7 A6NLF1 Q9UH74 B2RMN5 Q9UK86
|
| Accessions |
EAW76254 EAW76255 Q14686 AF128458 AAF37003 AF171667 AAF71829 AF177388 AAF13595 AF208227 AAF16403 AF245115 AAF78480 AI498955 AK027040 BC035676 BC047886 BC069829 BC114613 AAI14614 BC136272 AAI36273 BU187688 D80003 BAA11498 JF707637 AEG79564 JF707638 AEG79565 JF707639 AEG79566 L37706 XM_006723755 XP_006723818 XM_011528721 XP_011527023 XM_011528722 XP_011527024 XM_011528723 XP_011527025 XM_011528724 XP_011527026 XM_011528725 XP_011527027 XM_011528726 XP_011527028 XM_011528727 XP_011527029 XM_011528728 XP_011527030 XM_011528729 XP_011527031 XM_011528730 XP_011527032 XM_011528731 XP_011527033 XM_011528732 XP_011527034 XM_011528733 XP_011527035 XM_011528734 XP_011527036 XM_011528735 XP_011527037 XR_936514 XR_936515 NM_001242539 NP_001229468 NM_014071 NP_054790
|
| Function |
Nuclear receptor coactivator that directly binds nuclear receptors and stimulates the transcriptional activities in a hormone-dependent fashion. Coactivates expression in an agonist- and AF2-dependent manner. Involved in the coactivation of different nuclear receptors, such as for steroids (GR and ERs), retinoids (RARs and RXRs), thyroid hormone (TRs), vitamin D3 (VDR) and prostanoids (PPARs). Probably functions as a general coactivator, rather than just a nuclear receptor coactivator. May also be involved in the coactivation of the NF-kappa-B pathway. May coactivate expression via a remodeling of chromatin and its interaction with histone acetyltransferase proteins.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Ubiquitous. Highly expressed in brain, prostate, testis and ovary; weakly expressed in lung, thymus and small intestine.
|