Gene Symbol | MUM1 |
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Entrez Gene | 84939 |
Alt Symbol | EXPAND1, HSPC211, MUM-1 |
Species | Human |
Gene Type | protein-coding |
Description | melanoma associated antigen (mutated) 1 |
Other Description | PWWP domain-containing protein MUM1|melanoma ubiquitous mutated protein|mutated melanoma-associated antigen 1|protein expandere |
Swissprots | A1L489 B5ME02 Q8N2I4 J3KQD6 Q2TAK8 B7ZLY8 Q5XKB9 Q13109 Q96A67 |
Accessions | AAC50238 EAW69509 EAW69511 EAW69512 EAW69513 EAW69514 Q2TAK8 AF151045 AAF36131 AK025936 BAB15287 AK027774 BAB55357 AK075241 BAC11493 AK309092 AK310721 AL360266 CAB96179 BC001806 BC008098 AAH08098 BC019585 BC021016 BC082987 AAH82987 BC110874 AAI10875 BC130443 AAI30444 BC144138 AAI44139 BC144147 BG723598 BI553935 BQ071619 BQ895780 BU541563 BU741593 CR457395 CAG33676 DA739708 DN993266 U20896 AAC50239 U20897 AAC50240 XM_011528380 XP_011526682 XM_011528381 XP_011526683 XM_011528382 XP_011526684 XM_011528383 XP_011526685 XM_011528384 XP_011526686 XM_011528385 XP_011526687 NM_032853 NP_116242 NR_024247 |
Function | Involved in the DNA damage response pathway by contributing to the maintenance of chromatin architecture. Recruited to the vicinity of DNA breaks by TP53BP1 and plays an accessory role to facilitate damage-induced chromatin changes and promoting chromatin relaxation. Required for efficient DNA repair and cell survival following DNA damage. {ECO:0000269|PubMed:20347427}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:20347427}. Note=Recuited to DNA damage sites via its interaction with the BRCT domain of TP53BP1. |
MUM1 CRISPR/Cas9 KO Plasmid (h) - sc-408544 from Santa Cruz Biotechnology
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MUM1 HDR Plasmid (h) - sc-408544-HDR from Santa Cruz Biotechnology
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MUM1 Double Nickase Plasmid (h) - sc-408544-NIC from Santa Cruz Biotechnology
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MUM1 Double Nickase Plasmid (h2) - sc-408544-NIC-2 from Santa Cruz Biotechnology
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MUM1 CRISPR Activation Plasmid (h) - sc-408544-ACT from Santa Cruz Biotechnology
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MUM1 CRISPR Activation Plasmid (h2) - sc-408544-ACT-2 from Santa Cruz Biotechnology
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MUM1 Lentiviral Activation Particles (h) - sc-408544-LAC from Santa Cruz Biotechnology
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MUM1 Lentiviral Activation Particles (h2) - sc-408544-LAC-2 from Santa Cruz Biotechnology
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MUM1 siRNA (h) - sc-97721 from Santa Cruz Biotechnology
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MUM1 shRNA Plasmid (h) - sc-97721-SH from Santa Cruz Biotechnology
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MUM1 shRNA (h) Lentiviral Particles - sc-97721-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU099871 from Sigma-Aldrich
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MISSION® esiRNA - EHU098141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN14766 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14766 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10385 from Sigma-Aldrich
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MUM1 siRNA (Human) - CRJ3710 from Cohesion Biosciences
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shRNA set against Human MUM1 (NM_032853.3) - SHH347048 from Creative biogene
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Human MUM1 siRNA - orb274211 from Biorbyt
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MUM1 shRNA Plasmid (Human) - CHJ3710 from Cohesion Biosciences
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MUM1 miRNA 3'UTR clone - MiUTR3H-15547 from Creative biogene
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