UBE3A

Gene Symbol	UBE3A
Entrez Gene	7337
Alt Symbol	ANCR, AS, E6-AP, EPVE6AP, HPVE6A
Species	Human
Gene Type	protein-coding
Description	ubiquitin protein ligase E3A
Other Description	CTCL tumor antigen se37-2|E6AP ubiquitin-protein ligase|human papilloma virus E6-associated protein|human papillomavirus E6-associated protein|oncogenic protein-associated protein E6-AP|renal carcinoma antigen NY-REN-54|ubiquitin-protein ligase E3A
Swissprots	Q9UEP7 Q9UEP9 Q9UEP8 Q93066 P78355 Q05086 A8K8Z9 Q9UEP4 Q9UEP5 Q9UEP6
Accessions	AAB69154 CAA04534 CAA04535 CAA04536 CAA04537 CAA04538 CAA04539 CAA04540 CAA66653 EAW57642 EAW57643 EAW57644 EAW57645 Q05086 AB194232 BAD69553 AF002224 AF002225 AF273050 AAG34910 AI378869 AK056239 AK130491 AK291405 BAF84094 AK292514 BAF85203 AL049363 AL831842 BC002582 AAH02582 BC009271 AAH09271 BE349076 DA415876 JF432815 ADZ16032 L07557 AAA35542 U84404 AAB49301 X98031 CAA66654 X98032 CAA66655 X98033 CAA66656 XM_005268267 XP_005268324 XM_005268268 XP_005268325 XM_005268269 XP_005268326 XM_005268270 XP_005268327 XM_005268271 XP_005268328 XM_006720673 XP_006720736 XM_006720674 XP_006720737 XM_006720675 XP_006720738 XM_006720676 XP_006720739 XM_011521994 XP_011520296 XM_011521995 XP_011520297 XM_011521996 XP_011520298 NM_000462 NP_000453 NM_130838 NP_570853 NM_130839 NP_570854
Function	E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). {ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0
Subcellular Location	Nucleus {ECO:0000250|UniProtKB:O08759}. Cytoplasm {ECO:0000250|UniProtKB:O08759}.
Top Pathways	Ubiquitin mediated proteolysis, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UBE3A cDNA clone(NM_130838.1) - CDFG007630 from Creative Biomart Species Human Accession NM_130838.1

Human UBE3A ORF Clone(NM_000462.3) - CDCL180340 from Creative Biomart Species Human Accession NM_000462.3

Human UBE3A ORF Clone(NM_000462.3) - CDCL180341 from Creative Biomart Species Human Accession NM_000462.3

Human UBE3A ORF Clone(NM_000462.3) - CDCL180342 from Creative Biomart Species Human Accession NM_000462.3

Human UBE3A ORF Clone(NM_130838.1) - CDCR315853 from Creative Biomart Species Human Accession NM_130838.1

Human UBE3A ORF Clone(NM_130838.1) - CDCR315854 from Creative Biomart Species Human Accession NM_130838.1

Human UBE3A ORF Clone(NM_130839.2) - CDCR315855 from Creative Biomart Species Human Accession NM_130839.2

Human UBE3A ORF Clone(NM_130839.2) - CDCR315856 from Creative Biomart Species Human Accession NM_130839.2

Human E6AP transcript variant 1 Gene ORF cDNA clone in cloning vector - HG11130-M from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, C-HA tag - HG11130-CY from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid - HG11130-M-N from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid - HG11130-UT from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG11130-ACG from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, N-HA tag - HG11130-NY from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, N-His tag - HG11130-NH from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG11130-NF from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG11130-NM from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG11130-ANG from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG11130-CF from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, C-His tag - HG11130-CH from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG11130-CM from Sino Biological Species Human

Human E6AP transcript variant 1 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG11130-ACR from Sino Biological Species Human

Human E6AP ORF clone(NM_130838.1) - CDCL183973 from Creative biogene Species Human

Human UBE3A ORF Clone(NM_130839.2) - CDCR315856 from Creative biogene Species Human

Human UBE3A ORF Clone (BC009271) - CDCS405675 from Creative biogene Species Human Accession Q05086

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