UBE3A

Gene Symbol UBE3A
Entrez Gene 7337
Alt Symbol ANCR, AS, E6-AP, EPVE6AP, HPVE6A
Species Human
Gene Type protein-coding
Description ubiquitin protein ligase E3A
Other Description CTCL tumor antigen se37-2|E6AP ubiquitin-protein ligase|human papilloma virus E6-associated protein|human papillomavirus E6-associated protein|oncogenic protein-associated protein E6-AP|renal carcinoma antigen NY-REN-54|ubiquitin-protein ligase E3A
Swissprots Q9UEP7 Q9UEP9 Q9UEP8 Q93066 P78355 Q05086 A8K8Z9 Q9UEP4 Q9UEP5 Q9UEP6
Accessions AAB69154 CAA04534 CAA04535 CAA04536 CAA04537 CAA04538 CAA04539 CAA04540 CAA66653 EAW57642 EAW57643 EAW57644 EAW57645 Q05086 AB194232 BAD69553 AF002224 AF002225 AF273050 AAG34910 AI378869 AK056239 AK130491 AK291405 BAF84094 AK292514 BAF85203 AL049363 AL831842 BC002582 AAH02582 BC009271 AAH09271 BE349076 DA415876 JF432815 ADZ16032 L07557 AAA35542 U84404 AAB49301 X98031 CAA66654 X98032 CAA66655 X98033 CAA66656 XM_005268267 XP_005268324 XM_005268268 XP_005268325 XM_005268269 XP_005268326 XM_005268270 XP_005268327 XM_005268271 XP_005268328 XM_006720673 XP_006720736 XM_006720674 XP_006720737 XM_006720675 XP_006720738 XM_006720676 XP_006720739 XM_011521994 XP_011520296 XM_011521995 XP_011520297 XM_011521996 XP_011520298 NM_000462 NP_000453 NM_130838 NP_570853 NM_130839 NP_570854
Function E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Catalyzes the high-risk human papilloma virus E6-mediated ubiquitination of p53/TP53, contributing to the neoplastic progression of cells infected by these viruses. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo. Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990). {ECO:0000269|PubMed:10373495, ECO:0000269|PubMed:19204938, ECO:0000269|PubMed:19233847, ECO:0
Subcellular Location Nucleus {ECO:0000250|UniProtKB:O08759}. Cytoplasm {ECO:0000250|UniProtKB:O08759}.
Top Pathways Ubiquitin mediated proteolysis, Viral carcinogenesis

E6-AP CRISPR/Cas9 KO Plasmid (h) - sc-401632 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP HDR Plasmid (h) - sc-401632-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP Double Nickase Plasmid (h) - sc-401632-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP Double Nickase Plasmid (h2) - sc-401632-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP CRISPR Activation Plasmid (h) - sc-401632-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP CRISPR Activation Plasmid (h2) - sc-401632-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP Lentiviral Activation Particles (h) - sc-401632-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP Lentiviral Activation Particles (h2) - sc-401632-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

E6-AP siRNA (h) - sc-43742 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

E6-AP shRNA Plasmid (h) - sc-43742-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

E6-AP shRNA (h) Lentiviral Particles - sc-43742-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

E6AP/UBE3A RNAi - H00007337-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

E6AP/UBE3A RNAi - H00007337-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

E6AP/UBE3A RNAi - H00007337-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU113061 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22392 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22392 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UBE3A siRNA (Human) - CRH5017 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBE3A - MBS828920 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human UBE3A (NM_000462.3) - SHH439252 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human UBE3A(NM_130838.1) - SHG057475 from Creative biogene

Category siRNA
Species Reactivities Human

Human UBE3A siRNA - orb265519 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UBE3A shRNA Plasmid (Human) - CHH5017 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UBE3A miRNA 3'UTR clone - MiUTR3H-04261 from Creative biogene

Species Reactivities Human

UBE3A miRNA 3'UTR clone - MiUTR3H-04262 from Creative biogene

Species Reactivities Human
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