| Gene Symbol |
DHX36
|
| Entrez Gene |
170506
|
| Alt Symbol |
DDX36, G4R1, MLEL1, RHAU
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEAH (Asp-Glu-Ala-His) box polypeptide 36
|
| Other Description |
ATP-dependent RNA helicase DHX36|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36|DEAH box protein 36|G4 resolvase-1|G4-resolvase 1|MLE-like protein 1|RNA helicase associated with AU-rich element ARE|probable ATP-dependent RNA helicase DHX36
|
| Swissprots |
Q9H2U1 Q70JU3 Q9P240 B2RB00 Q8IYE5
|
| Accessions |
EAW78761 EAW78762 EAW78763 Q9H2U1 AB040921 BAA96012 AF217190 AAG36783 AJ577133 CAE11802 AJ577134 CAE11803 AK096808 AK303720 BAH14031 AK314435 BAG37047 BC036035 AAH36035 DQ891010 ABM81936 NM_001114397 NP_001107869 NM_020865 NP_065916
|
| Function |
Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398, ECO:0
|
| Subcellular Location |
Nucleus. Cytoplasm. Chromosome, telomere {ECO:0000305}. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules.
|
| Tissue Specificity |
Highly expressed in testis. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398}.
|
| Top Pathways |
RNA degradation
|