DHX36

Gene Symbol	DHX36
Entrez Gene	170506
Alt Symbol	DDX36, G4R1, MLEL1, RHAU
Species	Human
Gene Type	protein-coding
Description	DEAH (Asp-Glu-Ala-His) box polypeptide 36
Other Description	ATP-dependent RNA helicase DHX36|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36|DEAH box protein 36|G4 resolvase-1|G4-resolvase 1|MLE-like protein 1|RNA helicase associated with AU-rich element ARE|probable ATP-dependent RNA helicase DHX36
Swissprots	Q9H2U1 Q70JU3 Q9P240 B2RB00 Q8IYE5
Accessions	EAW78761 EAW78762 EAW78763 Q9H2U1 AB040921 BAA96012 AF217190 AAG36783 AJ577133 CAE11802 AJ577134 CAE11803 AK096808 AK303720 BAH14031 AK314435 BAG37047 BC036035 AAH36035 DQ891010 ABM81936 NM_001114397 NP_001107869 NM_020865 NP_065916
Function	Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398, ECO:0
Subcellular Location	Nucleus. Cytoplasm. Chromosome, telomere {ECO:0000305}. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules.
Tissue Specificity	Highly expressed in testis. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DDX36 CRISPR/Cas9 KO Plasmid (h) - sc-404744 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 HDR Plasmid (h) - sc-404744-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 Double Nickase Plasmid (h) - sc-404744-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 Double Nickase Plasmid (h2) - sc-404744-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 CRISPR Activation Plasmid (h) - sc-404744-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 CRISPR Activation Plasmid (h2) - sc-404744-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 Lentiviral Activation Particles (h) - sc-404744-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 Lentiviral Activation Particles (h2) - sc-404744-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DDX36 siRNA (h) - sc-78053 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DDX36 shRNA Plasmid (h) - sc-78053-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DDX36 shRNA (h) Lentiviral Particles - sc-78053-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DHX36 RNAi - H00170506-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU083701 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN7220 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND7220 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR04124 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr04124

DHX36 siRNA (Human) - CRJ6112 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DHX36 - MBS8238643 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human DHX36 (NM_020865.2) - SHH277909 from Creative biogene Category siRNA Species Reactivities Human

Human DHX36 siRNA - orb276613 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DHX36 shRNA Plasmid (Human) - CHJ6112 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

DHX36 miRNA 3'UTR clone - MiUTR1H-02818 from Creative biogene Species Reactivities Human

DHX36 miRNA 3'UTR clone - MiUTR3H-12589 from Creative biogene Species Reactivities Human

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