DHX36

Gene Symbol DHX36
Entrez Gene 170506
Alt Symbol DDX36, G4R1, MLEL1, RHAU
Species Human
Gene Type protein-coding
Description DEAH (Asp-Glu-Ala-His) box polypeptide 36
Other Description ATP-dependent RNA helicase DHX36|DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 36|DEAH box protein 36|G4 resolvase-1|G4-resolvase 1|MLE-like protein 1|RNA helicase associated with AU-rich element ARE|probable ATP-dependent RNA helicase DHX36
Swissprots Q9H2U1 Q70JU3 Q9P240 B2RB00 Q8IYE5
Accessions EAW78761 EAW78762 EAW78763 Q9H2U1 AB040921 BAA96012 AF217190 AAG36783 AJ577133 CAE11802 AJ577134 CAE11803 AK096808 AK303720 BAH14031 AK314435 BAG37047 BC036035 AAH36035 DQ891010 ABM81936 NM_001114397 NP_001107869 NM_020865 NP_065916
Function Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component (TERC) 5'-end (nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398, ECO:0
Subcellular Location Nucleus. Cytoplasm. Chromosome, telomere {ECO:0000305}. Note=Isoform 1 preferentially localized to the nucleus and isoform 2 localized to the cytoplasm. However, partitioning of cellular localization between the nucleus and cytoplasm is not exclusive, as isoform 1 was also detected in the cytoplasm. Both isoforms were excluded from nucleoli. Localizes to cytoplasmic stress granules.
Tissue Specificity Highly expressed in testis. {ECO:0000269|PubMed:12198572, ECO:0000269|PubMed:14731398}.
Top Pathways RNA degradation

DDX36 (E-4) - sc-398418 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DDX36 (E-4): sc-398418. Western blot analysis of DDX36 expression in Raji (A), NTERA-2 cl.D1 (B), Ramos (C), K-562 (D) and BJAB (E) whole cell lysates.

DDX36 (N-16) - sc-99376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
DDX36 (N-16): sc-99376. Western blot analysis of DDX36 expression in K-562 (A), Ramos (B), Raji (C), NTERA-2 cl.D1 (D) and BJAB (E) whole cell lysates and mouse testis tissue extract (F).

DDX36 (B-6) - sc-377485 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
DDX36 (B-6): sc-377485. Western blot analysis of DDX36 expression in K-562 (A) and Ramos (B) whole cell lysates.

DDX36 (H-124) - sc-366460 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-DHX36 antibody - ab70269 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human testicular seminoma tissue labelling DHX36 with ab70269 at 1/1000 (1µg/ml). Detection: DAB.

Anti-DHX36 antibody - ab156279 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-DHX36 antibody (ab156279) at 0.5 µg/mlLane 2 : Anti-DHX36 antibody (ab156279) at 1 µg/mlLane 1 : Mouse liver tissue extractLane 2 : Mouse liver tissue extractLysates/proteins at 15 µg per lane.developed using the ECL technique

Anti-DHX36 antibody - ab138779 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-DHX36 antibody (ab138779) at 1/100 dilution + HepG2 cell line lysates at 35 µg

Anti-DHX36 Antibody (C-Terminus) - LS-C64847 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody (aa394-420, APC) - LS-C234582 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody (aa394-420, Biotin) - LS-C234583 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody (aa394-420) - LS-C159458 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
DHX36 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The DHX36 antibody detected the DHX36 protein (arrow).

Anti-DHX36 Antibody (aa394-420, AP) - LS-C234581 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody (aa394-420, PE) - LS-C234585 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody (aa394-420, FITC) - LS-C234584 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody (aa394-420, Azide-free, HRP) - LS-C249830 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody (aa393-420) - LS-C320839 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DHX36 Antibody - LS-C333910 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using DHX36 antibody.

Anti-DHX36 Antibody (C-Terminus) IHC-plus™ - LS-B10068 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-DHX36 antibody IHC staining of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10068 concentration 10 ug/ml.

Anti-DHX36 Antibody (C-Terminus) - LS-C287410 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human DHX36 by Immunohistochemistry. Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-DHX36 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

DHX36 Antibody - NB200-353 from Novus Biologicals

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: DHX36 Antibody [NB200-353] - Sample: FFPE section of human testicular seminoma. Antibody: Affinity purified rabbit anti-DHX36 used at a dilution of 1:1,000 (1ug/ml). Detection: DAB

DHX36 Antibody - NBP1-84286 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: DHX36 Antibody [NBP1-84286] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

Anti-DHX36 antibody produced in rabbit - HPA035399 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-DHX36: <B>Cat. No. HPA035399</B>: Immunohistochemical staining of human testis shows strong nuclear and cytoplasmic positivity in cells of seminiferus ducts.

Anti-DHX36 antibody produced in rabbit - SAB3500822 from Sigma-Aldrich

Prices $341.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>DHX36 Antibody: <B>Cat. No. SAB3500822</B>: Western blot analysis of DHX36 in Mouse liver tissue lysate with DHX36 antibody at (A) 0.5 and (B) 1 μg/mL.

ANTI-DHX36 (CENTER) antibody produced in rabbit - SAB1305216 from Sigma-Aldrich

Prices $326.00
Sizes 40 tst
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-DHX36 (Center): <B>Cat. No. SAB1305216</B>: DHX36 Antibody(Center) western blot analysis in HepG2 cell line lysates (35 μg/lane).

DHX36-Antibody-Center - AP18778c from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
DHX36 Antibody (Center)(Cat. #AP18778c) western blot analysis in HepG2 cell line lysates (35ug/lane).This demonstrates the DHX36 antibody detected the DHX36 protein (arrow).
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