RNF111

Gene Symbol RNF111
Entrez Gene 54778
Alt Symbol ARK
Species Human
Gene Type protein-coding
Description ring finger protein 111
Other Description Arkadia|E3 ubiquitin-protein ligase Arkadia
Swissprots Q8N1P9 Q7L428 H0YN55 Q6P9A4 C9JUS4 Q6ZNA4 Q8WUA3 Q9NSR1 Q7Z346 Q6ZMU2
Accessions EAW77554 EAW77555 EAW77556 EAW77557 EAW77558 EAW77559 EAW77560 EAW77561 EAW77562 Q6ZNA4 AI189975 AK095327 BAC04531 AK131304 BAD18471 AK131488 BAD18633 AL157474 CAB75669 AL832089 BC010369 AAH10369 BC020984 AAH20984 BC060862 AAH60862 BM986870 BX538130 CAD98031 BX647259 CN420669 DA720863 N24855 XM_005254479 XP_005254536 XM_006720575 XP_006720638 XM_006720579 XP_006720642 XM_011521694 XP_011519996 XM_011521695 XP_011519997 XM_011521696 XP_011519998 XM_011521697 XP_011519999 XM_011521698 XP_011520000 XM_011521699 XP_011520001 XM_011521700 XP_011520002 NM_001270528 NP_001257457 NM_001270529 NP_001257458 NM_001270530 NP_001257459 NM_017610 NP_060080
Function Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme. {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17591695, ECO:0000269|PubMed:22411132}.
Subcellular Location Nucleus {ECO:0000269|PubMed:16601693}. Cytoplasm {ECO:0000269|PubMed:16601693}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.
Tissue Specificity Broadly expressed. {ECO:0000269|PubMed:14657019}.

Arkadia (H-16) - sc-21588 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Arkadia (H-16): sc-21588. Western blot analysis of Arkadia expression in HeLa whole cell lysate.

Arkadia (H-88) - sc-367716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Arkadia (1-KK14) - sc-134270 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
Arkadia (1-KK14): sc-134270. Western blot analysis of Arkadia expression in human Arkadia transfected (A) and non-transfected (B) 293T whole cell lysates.

Anti-RNF111 antibody - ab88535 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-RNF111 antibody (ab88535) at 1 µg/ml + Rat brain lysate at 50 µg

Anti-RNF111 antibody - ab197851 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of U2OS cells transfected with Flag-RNF111 labeling RNF111 in Red and Flag in green(IF: PFA fixation, methanol permeabilization, ab197851 at 1:600 dilution in PBST)

Anti-RNF111 antibody - ab57416 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Western blot against tagged recombinant protein immunogen using ab57416 RNF111 antibody at 1ug/ml.

Anti-RNF111 antibody - ab138086 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-RNF111 antibody (ab138086) at 1/500 dilution + Jurkat cell lysate at 30 µg

Anti-RNF111 antibody - N-terminal - ab174624 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RNF111 antibody - N-terminal (ab174624) at 1/100 dilution + A549 cell line lysates at 35 µg

Anti-Arkadia / RNF111 Antibody (aa208-237, AP) - LS-C240051 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa208-237, Biotin) - LS-C240054 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa208-237, APC) - LS-C240053 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa208-237, FITC) - LS-C240055 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa208-237, PE) - LS-C240056 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa208-237, Azide-free, HRP) - LS-C248012 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa901-950) - LS-C291323 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa208-237) - LS-C324715 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-Arkadia / RNF111 Antibody (aa889-938) - LS-C200607 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from Jurkat cells using RNF111 antibody.

Anti-Arkadia / RNF111 Antibody (aa208-237) - LS-C158860 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RNF111 Antibody western blot of A549 cell line lysates (35 ug/lane). The RNF111 antibody detected the RNF111 protein (arrow).

RNF111 Antibody - NBP1-94140 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RNF111 Antibody [NBP1-94140] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp

RNF111 Antibody (1C4) - H00054778-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C4

RNF111 Antibody - H00054778-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: RNF111 Antibody [H00054778-B01P] - Analysis of RNF111 expression in rat brain.

RNF111 Antibody - NBP1-94139 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: RNF111 Antibody [NBP1-94139] - Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.

RNF111 Antibody - H00054778-D01P from Novus Biologicals

Prices $399.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: RNF111 Antibody [H00054778-D01P] - Analysis of RNF111 expression in NIH/3T3.

Monoclonal Anti-RNF111 antibody produced in mouse - WH0054778M5 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1C4
<B>Immunoblotting</B><BR/>Monoclonal Anti-RNF111, <B>Cat. No. WH0054778M5</B> used at the antibody concentration: 1 μg/mL. Specific band of ~37.99 kDa using immunogen protein lysate.

Anti-RNF111 antibody produced in mouse - SAB1407572 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-RNF111: <B>Cat. No. SAB1407572</B>: Antibody concentration: 3 μg/mL using human prostate tissue.
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