| Gene Symbol |
RNF111
|
| Entrez Gene |
54778
|
| Alt Symbol |
ARK
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ring finger protein 111
|
| Other Description |
Arkadia|E3 ubiquitin-protein ligase Arkadia
|
| Swissprots |
Q8N1P9 Q7L428 H0YN55 Q6P9A4 C9JUS4 Q6ZNA4 Q8WUA3 Q9NSR1 Q7Z346 Q6ZMU2
|
| Accessions |
EAW77554 EAW77555 EAW77556 EAW77557 EAW77558 EAW77559 EAW77560 EAW77561 EAW77562 Q6ZNA4 AI189975 AK095327 BAC04531 AK131304 BAD18471 AK131488 BAD18633 AL157474 CAB75669 AL832089 BC010369 AAH10369 BC020984 AAH20984 BC060862 AAH60862 BM986870 BX538130 CAD98031 BX647259 CN420669 DA720863 N24855 XM_005254479 XP_005254536 XM_006720575 XP_006720638 XM_006720579 XP_006720642 XM_011521694 XP_011519996 XM_011521695 XP_011519997 XM_011521696 XP_011519998 XM_011521697 XP_011519999 XM_011521698 XP_011520000 XM_011521699 XP_011520001 XM_011521700 XP_011520002 NM_001270528 NP_001257457 NM_001270529 NP_001257458 NM_001270530 NP_001257459 NM_017610 NP_060080
|
| Function |
Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme. {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17591695, ECO:0000269|PubMed:22411132}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:16601693}. Cytoplasm {ECO:0000269|PubMed:16601693}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.
|
| Tissue Specificity |
Broadly expressed. {ECO:0000269|PubMed:14657019}.
|