RNF111

Gene Symbol	RNF111
Entrez Gene	54778
Alt Symbol	ARK
Species	Human
Gene Type	protein-coding
Description	ring finger protein 111
Other Description	Arkadia|E3 ubiquitin-protein ligase Arkadia
Swissprots	Q8N1P9 Q7L428 H0YN55 Q6P9A4 C9JUS4 Q6ZNA4 Q8WUA3 Q9NSR1 Q7Z346 Q6ZMU2
Accessions	EAW77554 EAW77555 EAW77556 EAW77557 EAW77558 EAW77559 EAW77560 EAW77561 EAW77562 Q6ZNA4 AI189975 AK095327 BAC04531 AK131304 BAD18471 AK131488 BAD18633 AL157474 CAB75669 AL832089 BC010369 AAH10369 BC020984 AAH20984 BC060862 AAH60862 BM986870 BX538130 CAD98031 BX647259 CN420669 DA720863 N24855 XM_005254479 XP_005254536 XM_006720575 XP_006720638 XM_006720579 XP_006720642 XM_011521694 XP_011519996 XM_011521695 XP_011519997 XM_011521696 XP_011519998 XM_011521697 XP_011519999 XM_011521698 XP_011520000 XM_011521699 XP_011520001 XM_011521700 XP_011520002 NM_001270528 NP_001257457 NM_001270529 NP_001257458 NM_001270530 NP_001257459 NM_017610 NP_060080
Function	Acts in the NODAL pathway of mesoderm patterning during embryonic development. Acts downstream AXIN1 as an E3 ubiquitin- protein ligase which promotes the ubiquitination of inhibitory SMADs such as SMAD7, induces their proteasomal degradation and thereby enhances the transcriptional activity of TGF-beta and BMP. Activates Smad3/Smad4-dependent transcription by triggering signal-induced SnoN degradation. Associates with UBE2D2 as an E2 enzyme. {ECO:0000269|PubMed:14657019, ECO:0000269|PubMed:16601693, ECO:0000269|PubMed:17591695, ECO:0000269|PubMed:22411132}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:16601693}. Cytoplasm {ECO:0000269|PubMed:16601693}. Note=Upon TGF-beta treatment, translocates from nucleus to cytosol.
Tissue Specificity	Broadly expressed. {ECO:0000269|PubMed:14657019}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human RNF111 protein fragment - ab162838 from Abcam Category Protein Source Wheat germ Species Human

Arkadia / RNF111 Antibody Blocking Peptide - LS-E5983 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human RNF111 Protein - H00054778-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RNF111-Antibody-N-term-Blocking-Peptide - BP18547a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

RNF111 Blocking Peptide - 33R-9114 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

RNF111 - H00054778-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RNF111 - H00054778-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RNF111 fusion protein - Ag6340 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human RNF111, His-tagged - RNF111-2333H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 ubiquitin-protein ligase Arkadia(RNF111) ,partial - CSB-YP741051HU CSB-EP741051HU CSB-BP741051HU CSB-MP741051HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RNF111 Recombinant Protein Antigen - NBP1-94140PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RNF111 Protein - NBP1-94139PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

RNF111 Peptide, Human - M34GP13368H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 ubiquitin-protein ligase Arkadia (RNF111), partial, Recombinant Protein - MBS1437295 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more