| Gene Symbol |
SLC51B
|
| Entrez Gene |
123264
|
| Alt Symbol |
OSTB, OSTBETA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 51, beta subunit
|
| Other Description |
OST-beta|organic solute transporter beta subunit|organic solute transporter subunit beta|solute carrier family 51 subunit beta
|
| Swissprots |
Q3SYF5 Q86UW2
|
| Accessions |
EAW77708 Q86UW2 AA156136 AA621440 AI793107 AK129601 AY194242 AAP23992 BC103842 AAI03843 BC103843 AAI03844 BC103844 AAI03845 XM_005254159 XP_005254216 NM_178859 NP_849190
|
| Function |
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids. Modulates SLC51A glycosylation, membrane trafficking and stability activities. {ECO:0000269|PubMed:16317684}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}; Single-pass membrane protein {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}. Note=Mainly restricted to the lateral and basal membranes of ileal enterocytes.
|
| Tissue Specificity |
Widely expressed with a high expression in ileum. Expressed in testis, colon, liver, small intestine, kidney, ovary and adrenal gland; and at low levels in heart, lung, brain, pituitary, thyroid gland, uterus, prostate, mammary gland and fat. {ECO:0000269|PubMed:12719432, ECO:0000269|PubMed:16317684}.
|
| Top Pathways |
Bile secretion
|
![Western Blot: OSTB Overexpression Lysate (Adult Normal) [NBP2-04938] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for OSTB.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9403_OSTB%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-04938-img0001.jpg)