RPA2

Gene Symbol	RPA2
Entrez Gene	6118
Alt Symbol	REPA2, RP-A p32, RP-A p34, RPA32
Species	Human
Gene Type	protein-coding
Description	replication protein A2, 32kDa
Other Description	RF-A protein 2|replication factor A protein 2|replication protein A 32 kDa subunit|replication protein A 34 kDa subunit
Swissprots	P15927 Q52II0 Q5TEJ5 Q5TEI9
Accessions	AAX84514 EAX07724 P15927 AK298759 BAG60901 AK300691 BAG62374 AK312956 BAG35795 BC001630 AAH01630 BC012157 AAH12157 BC021257 AAH21257 BG107669 BQ006360 BX333932 CR450348 CAG29344 DB025488 DQ892352 ABM83278 DQ895821 ABM86747 J05249 AAA36560 XM_011541897 XP_011540199 NM_001286076 NP_001273005 NM_001297558 NP_001284487 NM_002946 NP_002937
Function	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interacti
Subcellular Location	Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Top Pathways	DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RPA2-Over-expression-Lysate - LY11127a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

RPA2 293T Cell Transient Overexpression Lysate(Denatured) - H00006118-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

RPA2 293T Cell Transient Overexpression Lysate(Denatured) - H00006118-T02 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

RPA2 overexpression lysate - LY401031 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

RPA2 293 Cell Lysate - 400968 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

RPA2 Overexpression Lysate (Denatured) - H00006118-T02 from Novus Biologicals Category Cell Lysate Prices $299.00 Sizes 100 µl Species Human

RPA2 Overexpression Lysate (Denatured) - H00006118-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

RPA2 Overexpression Lysate (Native) - NBL1-15489 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

RPA 32 kDa subunit (h3): 293 Lysate - sc-158938 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

RPA2 Over-expression Lysate Product - GWB-A96EBE from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human RPA2 Knockdown Stable Cell Line - CSC-DC013480 from Creative biogene Category Cell Line Species Human

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