RPA2

Gene Symbol RPA2
Entrez Gene 6118
Alt Symbol REPA2, RP-A p32, RP-A p34, RPA32
Species Human
Gene Type protein-coding
Description replication protein A2, 32kDa
Other Description RF-A protein 2|replication factor A protein 2|replication protein A 32 kDa subunit|replication protein A 34 kDa subunit
Swissprots P15927 Q52II0 Q5TEJ5 Q5TEI9
Accessions AAX84514 EAX07724 P15927 AK298759 BAG60901 AK300691 BAG62374 AK312956 BAG35795 BC001630 AAH01630 BC012157 AAH12157 BC021257 AAH21257 BG107669 BQ006360 BX333932 CR450348 CAG29344 DB025488 DQ892352 ABM83278 DQ895821 ABM86747 J05249 AAA36560 XM_011541897 XP_011540199 NM_001286076 NP_001273005 NM_001297558 NP_001284487 NM_002946 NP_002937
Function As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interacti
Subcellular Location Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Top Pathways DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

RPA 32 kDa subunit CRISPR/Cas9 KO Plasmid (h) - sc-401249 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit HDR Plasmid (h) - sc-401249-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit Double Nickase Plasmid (h) - sc-401249-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit Double Nickase Plasmid (h2) - sc-401249-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit CRISPR Activation Plasmid (h) - sc-401249-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit CRISPR Activation Plasmid (h2) - sc-401249-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit Lentiviral Activation Particles (h) - sc-401249-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit Lentiviral Activation Particles (h2) - sc-401249-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RPA 32 kDa subunit siRNA (h) - sc-38229 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RPA 32 kDa subunit shRNA Plasmid (h) - sc-38229-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RPA 32 kDa subunit shRNA (h) Lentiviral Particles - sc-38229-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN18516 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18516 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05239 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05239

RPA2 siRNA (Human) - CRH4112 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RPA2 - MBS8207163 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RPA2 (NM_002946.3) - SHH397860 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human RPA2(NM_002946.3) - SHR187734 from Creative biogene

Category siRNA
Species Reactivities Human

Human RPA2 siRNA - orb264614 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RPA2 shRNA Plasmid (Human) - CHH4112 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RPA2 miRNA 3'UTR clone - MiUTR1H-08963 from Creative biogene

Species Reactivities Human
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