RPA2

Gene Symbol RPA2
Entrez Gene 6118
Alt Symbol REPA2, RP-A p32, RP-A p34, RPA32
Species Human
Gene Type protein-coding
Description replication protein A2, 32kDa
Other Description RF-A protein 2|replication factor A protein 2|replication protein A 32 kDa subunit|replication protein A 34 kDa subunit
Swissprots P15927 Q52II0 Q5TEJ5 Q5TEI9
Accessions AAX84514 EAX07724 P15927 AK298759 BAG60901 AK300691 BAG62374 AK312956 BAG35795 BC001630 AAH01630 BC012157 AAH12157 BC021257 AAH21257 BG107669 BQ006360 BX333932 CR450348 CAG29344 DB025488 DQ892352 ABM83278 DQ895821 ABM86747 J05249 AAA36560 XM_011541897 XP_011540199 NM_001286076 NP_001273005 NM_001297558 NP_001284487 NM_002946 NP_002937
Function As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response. It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage. Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair. Plays also a role in base excision repair (BER) probably through interacti
Subcellular Location Nucleus. Nucleus, PML body. Note=Redistributes to discrete nuclear foci upon DNA damage in an ATR-dependent manner.
Top Pathways DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

RPA32/RPA2 (4E4) Rat mAb - 2208 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rat
Clonality Monoclonal
Clone 4E4
Western blot analysis of extracts from various cell lines, using RPA32 (4E4) Rat mAb.

RPA 32 kDa subunit (B-4) - sc-271578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA 32 kDa subunit (B-4): sc-271578. Western blot analysis of RPA 32 kDa subunit expression in HeLa (A), H69AR (B) and T-47D (C) whole cell lysates.

RPA 32 kDa subunit (9H8) - sc-56770 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA 32 kDa subunit (9H8): sc-56770. Western blot analysis of RPA 32 kDa subunit expression in H69AR (A), HeLa (B), Saos-2 (C), T-47D (D) and MCF7 (E) whole cell lysates.

RPA 32 kDa subunit (G-3) - sc-166886 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA 32 kDa subunit (G-3): sc-166886. Western blot analysis of RPA 32 kDa subunit expression in 293T whole cell lysate.

RPA 32 kDa subunit (C-16) - sc-14692 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA 32 kDa subunit (C-16): sc-14692. Western blot analysis of RPA 32 kDa subunit expression in HeLa nuclear extract (A) and HeLa (B), H69AR (C), Saos-2 (D), MCF7 (E) and T-47D (F) whole cell lysates.

RPA 32 kDa subunit (K-17) - sc-46501 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RPA 32 kDa subunit (H-100) - sc-28709 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
RPA 32 kDa subunit (H-100): sc-28709. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

RPA 32 kDa subunit (MA34) - sc-53496 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA 32 kDa subunit (MA34): sc-53496. Western blot analysis of RPA 32 kDa subunit expression in HeLa (A), T-47D (B), MCF7 (C) and Saos-2 (D) whole cell lysates and Ramos (E) and HeLa (F) nuclear extracts.

RPA 32 kDa subunit (P-16) - sc-14691 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
RPA 32 kDa subunit (P-16): sc-14691. Western blot analysis of RPA 32 kDa subunit expression in MCF7 (A) and T-47D (B) whole cell lysates and HeLa (C) and MCF7 (D) nuclear extracts.

RPA 32 kDa subunit (V-12) - sc-46626 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

RPA 32 kDa subunit (SPM316) - sc-56594 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
RPA 32 kDa subunit (SPM316): sc-56594. Western blot analysis of RPA 32 kDa subunit expression in HeLa (A), T-47D (B), MCF7 (C) and Saos-2 (D) whole cell lysates and Ramos (E) and HeLa (F) nuclear extracts.

Anti-RPA32/RPA2 (phospho S33) antibody - ab87278 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of Human breast carcinoma using ab87278 at 1/250 dilution, with mock phosphatase treated section (left) or calf intestinal phosphatase treated section (right). Detection: DAB staining

Anti-RPA32/RPA2 (phospho S4 + S8) antibody - ab87277 from Abcam

Prices $378.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of Human breast carcinoma using ab87277 at 1/250 dilution, with mock phosphatase treated section (left) or calf intestinal phosphatase treated section (right). Detection: DAB staining.

Anti-RPA32/RPA2 (phospho T21) antibody - ab61065 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using ab61065 at 1/50-1/100 dilution with or without Phospho-peptide.

Anti-RPA32/RPA2 (phospho T21) antibody - ab192225 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-RPA32/RPA2 (phospho T21) antibody (ab192225) at 1/500 dilutionLane 1 : Adriamycin treated HeLa whole cell lysate with antigen-specific peptideLane 2 : Adriamycin treated HeLa whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-RPA32/RPA2 (phospho T21) antibody [EPR2846(2)] - ab109394 from Abcam

Prices $391.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR2846(2)
All lanes : Anti-RPA32/RPA2 (phospho T21) antibody [EPR2846(2)] (ab109394) at 1/50000 dilutionLane 1 : HeLa cell lysates, untreatedLane 2 : HeLa cell lysates, treated with CamptothecinLysates/proteins at 10 µg per lane.

Anti-RPA32/RPA2 antibody - ab10359 from Abcam

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling RPA32/RPA2 with ab10359 at 1/5000 (0.2µg/ml). Detection: DAB.

Anti-RPA32/RPA2 antibody - ab61184 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human lung carcinoma tissue using ab61184 at 1/50 dilution. Samples were treated -/+ blocking peptide.

Anti-RPA32/RPA2 antibody - ab88675 from Abcam

Prices $384.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-RPA32/RPA2 antibody (ab88675) at 1 µg/ml + human kidney tissue lysate at 50 µg

Anti-RPA32/RPA2 antibody - ab87315 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab87315, at a 1/250 dilution, staining RPA32/RPA2 in formalin fixed, paraffin embedded human ovarian tumor sections by Immunohistochemistry. Detection: DAB staining.

Anti-RPA32/RPA2 antibody - ab492 from Abcam

Prices $395.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

Anti-RPA32/RPA2 antibody [12F3.3] - ab478 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 12F3.3

Anti-RPA32/RPA2 antibody [2927C5] - ab51499 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2927C5
Anti-RPA32/RPA2 antibody [2927C5] (ab51499) at 1/200 dilution + HeLa whole cell lysate at 25 µgSecondaryAnti Mouse IgG at 1/2500 dilution

Anti-RPA32/RPA2 antibody [9A1] - ab125681 from Abcam

Prices $387.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 9A1
All lanes : Anti-RPA32/RPA2 antibody [9A1] (ab125681) at 1/1000 dilutionLane 1 : HEK293T cell lysate transfected with pCMV6-ENTRY control cDNALane 2 : HEK293T cell lysate transfected with pCMV6-ENTRY RPA32/RPA2 cDNALysates/proteins at 5 µg per lane.

Anti-RPA32/RPA2 antibody [9H8] - ab2175 from Abcam

Prices $404.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 9H8
ab2175 - immunohistochemistryFormalin fixed paraffin embedded human tonsil stained with RPA using ABC and AEC chromogen.
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