Gene Symbol | FA2H |
---|---|
Entrez Gene | 79152 |
Alt Symbol | FAAH, FAH1, FAXDC1, SCS7, SPG35 |
Species | Human |
Gene Type | protein-coding |
Description | fatty acid 2-hydroxylase |
Other Description | fatty acid alpha-hydroxylase|fatty acid hydroxylase domain containing 1|spastic paraplegia 35 (autosomal recessive) |
Swissprots | O75213 Q9H1A5 B7Z8T6 Q96DK1 Q7L5A8 |
Accessions | AAC23496 EAW95677 EAW95678 Q7L5A8 AA857184 AJ278219 CAC20436 AK058016 BAB71632 AK303878 BAH14072 AK315512 BAG37893 BC002679 AAH02679 BC004263 AAH04263 BC010453 BC017049 AAH17049 DA890369 XM_011523317 XP_011521619 XM_011523318 XP_011521620 XM_011523319 XP_011521621 NM_024306 NP_077282 |
Function | Required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids. {ECO:0000269|PubMed:15337768, ECO:0000269|PubMed:17355976}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15337768}; Multi-pass membrane protein {ECO:0000269|PubMed:15337768}. Microsome membrane {ECO:0000269|PubMed:15337768}; Multi-pass membrane protein {ECO:0000269|PubMed:15337768}. |
Tissue Specificity | Detected in differentiating cultured keratinocytes (at protein level). Detected in epidermis and cultured keratinocytes. Highly expressed in brain and colon. Detected at lower levels in testis, prostate, pancreas and kidney. {ECO:0000269|PubMed:15337768, ECO:0000269|PubMed:17355976}. |
FA2H CRISPR/Cas9 KO Plasmid (h) - sc-413143 from Santa Cruz Biotechnology
|
||||||||
FA2H HDR Plasmid (h) - sc-413143-HDR from Santa Cruz Biotechnology
|
||||||||
FA2H Double Nickase Plasmid (h) - sc-413143-NIC from Santa Cruz Biotechnology
|
||||||||
FA2H Double Nickase Plasmid (h2) - sc-413143-NIC-2 from Santa Cruz Biotechnology
|
||||||||
FA2H CRISPR Activation Plasmid (h) - sc-413143-ACT from Santa Cruz Biotechnology
|
||||||||
FA2H CRISPR Activation Plasmid (h2) - sc-413143-ACT-2 from Santa Cruz Biotechnology
|
||||||||
FA2H Lentiviral Activation Particles (h) - sc-413143-LAC from Santa Cruz Biotechnology
|
||||||||
FA2H Lentiviral Activation Particles (h2) - sc-413143-LAC-2 from Santa Cruz Biotechnology
|
||||||||
FA2H siRNA (h) - sc-93418 from Santa Cruz Biotechnology
|
||||||||
FA2H shRNA Plasmid (h) - sc-93418-SH from Santa Cruz Biotechnology
|
||||||||
FA2H shRNA (h) Lentiviral Particles - sc-93418-V from Santa Cruz Biotechnology
|
||||||||
FAAH RNAi - H00002166-R01 from Novus Biologicals
|
||||||||
MISSION® esiRNA - EHU049601 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN8076 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8076 from Sigma-Aldrich
|
||||||||
FA2H siRNA (Human) - CRJ2331 from Cohesion Biosciences
|
||||||||
FA2H - MBS8205091 from MyBioSource
|
||||||||
shRNA set against Human FA2H (NM_024306.4) - SHH288553 from Creative biogene
|
||||||||
FA2H shRNA Plasmid (Human) - CHJ2331 from Cohesion Biosciences
|
||||||||
FA2H miRNA 3'UTR clone - MiUTR4H-TG03225 from Creative biogene
|