MED23

Gene Symbol	MED23
Entrez Gene	9439
Alt Symbol	ARC130, CRSP130, CRSP133, CRSP3, DRIP130, MRT18, SUR-2, SUR2
Species	Human
Gene Type	protein-coding
Description	mediator complex subunit 23
Other Description	130 kDa transcriptional co-activator|133 kDa transcriptional co-activator|activator-recruited cofactor 130 kDa component|cofactor required for Sp1 transcriptional activation subunit 3|mediator of RNA polymerase II transcription subunit 23|vitamin D3 receptor interacting protein
Swissprots	Q9NTU0 Q5JWT3 Q6P9H6 Q5JWT4 B9TX55 Q9NTT9 Q9Y667 Q9ULK4 Q9Y5P7 O95403 Q9H0J2
Accessions	EAW48049 EAW48050 EAW48051 EAW48052 Q9ULK4 AB033042 BAA86530 AF104255 AAD12724 AF105332 AAD31729 AF135022 AAD30202 AI249380 AJ420587 AK304711 BAG65476 AK315030 AL136776 CAB66710 AM393572 CAL38449 AW295188 BC007088 AAH07088 BC060759 AAH60759 DB453121 EU392520 ACB88848 EU392521 ACB88849 EU392522 ACB88850 EU392523 ACB88851 EU392524 ACB88852 EU392525 ACB88853 EU392526 ACB88854 EU392527 ACB88855 EU392528 ACB88856 EU392529 ACB88857 EU392530 ACB88858 EU392531 ACB88859 EU392532 ACB88860 EU832308 ACE87565 EU832392 ACE86877 XM_005267223 XP_005267280 XM_006715612 XP_006715675 XM_011536257 XP_011534559 NM_001270521 NP_001257450 NM_001270522 NP_001257451 NM_004830 NP_004821 NM_015979 NP_057063
Function	Required for transcriptional activation subsequent to the assembly of the preinitiation complex (By similarity). Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for transcriptional activation by adenovirus E1A protein. Required for ELK1-dependent transcriptional activation in response to activated Ras signaling. {ECO:0000250, ECO:0000269|PubMed:10353252, ECO:0000269|PubMed:14759369, ECO:0000269|PubMed:16595664}.
Subcellular Location	Nucleus {ECO:0000305}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DRIP130 protein fragment - ab160486 from Abcam Category Protein Source Wheat germ Species Human

MED23 / SUR2 Antibody Blocking Peptide - LS-E12427 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MED23 Protein - H00009439-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

MED23 Peptide - NBP2-11246 from Novus Biologicals Category Peptide Prices $249.00 Sizes 250 µg

MED23 - H00009439-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MED23 - H00009439-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MED23 fusion protein - Ag5346 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MED23, GST-tagged - MED23-809H from Creative Biomart Category Protein Source E.coli Species Human

CRSP130 (F26) Peptide - BS9128P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Mediator of RNA polymerase II transcription subunit 23(MED23) - CSB-YP891548HU CSB-EP891548HU CSB-BP891548HU CSB-MP891548HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

SUR2 Blocking Peptide - abx061247 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

MED23 Peptide, Human - M34GP09368H from Creative Peptides Category Peptide Source Synthetic. Species Human

SUR2 Blocking Peptide - CBP5160 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat, Monkey

MED23 Recombinant Protein Antigen - NBP2-56372PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Mediator of RNA polymerase II transcription subunit 23 (MED23), partial, Recombinant Protein - MBS1436158 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

MED23 fusion protein - Ag27241 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

MED23 fusion protein - Ag27100 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

MED23 peptide - orb319306 from Biorbyt Category Peptide

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