EPS15

Gene Symbol EPS15
Entrez Gene 2060
Alt Symbol AF-1P, AF1P, MLLT5
Species Human
Gene Type protein-coding
Description epidermal growth factor receptor pathway substrate 15
Other Description ALL1 fused gene from chromosome 1|epidermal growth factor receptor substrate 15|protein AF-1p
Swissprots P42566 D3DPJ2 B2R8J7 Q5SRH4
Accessions CAR81473 CAS91489 EAX06822 EAX06823 EAX06824 P42566 AA789139 AF052132 AF331760 AK090936 BAG52249 AK129853 AK294297 BAH11726 AK308128 AK313396 BAG36194 AW949896 BC054006 AAH54006 BM681433 BX647676 CD657119 DA801048 DQ367924 ABD34786 U07707 AAA52101 Z29064 CAA82305 Z29070 XM_005270618 XP_005270675 XM_006710446 XP_006710509 XM_011540991 XP_011539293 NM_001159969 NP_001153441 NM_001981 NP_001972
Function Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.
Tissue Specificity Ubiquitously expressed.
Top Pathways Endocytosis

Eps15 Antibody - 8855 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from various cell lines using Eps15 Antibody.

Eps15 (D3K8R) Rabbit mAb - 12460 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D3K8R
Western blot analysis of extracts from various cell lines using Eps15 (D3K8R) Rabbit mAb.

Eps15 (G-3) - sc-374578 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Eps15 (G-3): sc-374578. Western blot analysis of Eps15 expression in HL-60 whole cell lysate.

Eps15 (E-3) - sc-390259 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Eps15 (E-3): sc-390259. Western blot analysis of Eps15 expression in AML-193 (A) and CCRF-CEM (B) whole cell lysates.

Eps15 (C-20) - sc-534 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Eps15 (C-20): sc-534. Western blot analysis of human recombinant Eps15 fusion protein.

Eps15 (H-896) - sc-1840 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Eps15 (H-896): sc-1840. Western blot analysis of Eps15 expression in NIH/3T3 whole cell lysate.

Eps15 (K-15) - sc-11716 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Eps15 (K-15): sc-11716. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic staining.

Eps15 (17) - sc-135898 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
Eps15 (17): sc-135898. Western blot analysis of Eps15 expression in Jurkat whole cell lysate.

Anti-EPS15 antibody - ab84810 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab84810, at 1/100 dilution, staining EPS15 in formalin-fixed, paraffin-embedded human testicular seminoma by Immunohistochemistry using a Red-fluorescent goat anti-rabbit IgG highly cross-adsorbed Hilyte PlusTM 555 secondary antibody at a dilution of 1/100.

Anti-EPS15 antibody [EP9280] - ab174291 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP9280
All lanes : Anti-EPS15 antibody [EP9280] (ab174291) at 1/1000 dilutionLane 1 : A431 cell lysateLane 2 : Jurkat cell lysateLane 3 : Human fetal brain tissue lysateLysates/proteins at 10 µg per lane.

Anti-EPS15 antibody - C-terminal - ab71272 from Abcam

Prices $304.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-EPS15 antibody - C-terminal (ab71272) at 1/100 dilution + HL60 cell line lysate at 35 µg

Anti-EPS15 Antibody (C-Terminus) - LS-C141796 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
EPS15 Antibody - Immunofluorescent staining of rat fibroblasts.

Anti-EPS15 Antibody (aa575-625) - LS-C286573 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human EPS15 by Immunohistochemistry. Sample: FFPE section of human prostate carcinoma. Antibody: Affinity purified rabbit anti-EPS15 used at a dilution of 1:500.

Anti-EPS15 Antibody (Internal, Biotin) - LS-C141791 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (Internal, DY650) - LS-C141792 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (aa794-843) - LS-C81882 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-EPS15 Antibody (Internal, DY488) - LS-C141793 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (Internal, HRP) - LS-C141794 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (Internal, DY550) - LS-C141795 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (C-Terminus, Biotin) - LS-C141797 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (C-Terminus, DY650) - LS-C141798 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (C-Terminus, DY488) - LS-C141799 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (C-Terminus, HRP) - LS-C141800 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-EPS15 Antibody (aa840-870) - LS-C99587 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of anti-EPS15 antibody in HL60 cell line lysate (35 ug/lane). EPS15 (arrow) was detected using the purified antibody.

Anti-EPS15 Antibody (C-Terminus, DY550) - LS-C141801 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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