EPS15

Gene Symbol	EPS15
Entrez Gene	2060
Alt Symbol	AF-1P, AF1P, MLLT5
Species	Human
Gene Type	protein-coding
Description	epidermal growth factor receptor pathway substrate 15
Other Description	ALL1 fused gene from chromosome 1|epidermal growth factor receptor substrate 15|protein AF-1p
Swissprots	P42566 D3DPJ2 B2R8J7 Q5SRH4
Accessions	CAR81473 CAS91489 EAX06822 EAX06823 EAX06824 P42566 AA789139 AF052132 AF331760 AK090936 BAG52249 AK129853 AK294297 BAH11726 AK308128 AK313396 BAG36194 AW949896 BC054006 AAH54006 BM681433 BX647676 CD657119 DA801048 DQ367924 ABD34786 U07707 AAA52101 Z29064 CAA82305 Z29070 XM_005270618 XP_005270675 XM_006710446 XP_006710509 XM_011540991 XP_011539293 NM_001159969 NP_001153441 NM_001981 NP_001972
Function	Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}.
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits.
Tissue Specificity	Ubiquitously expressed.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EPS15 Antibody Blocking Peptide - LS-E19667 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPS15 Antibody Blocking Peptide - LS-E6906 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

EPS15 Peptide - P0968 from Novus Biologicals Category Peptide Species Human

EPS15-Antibody-C-term-Blocking-Peptide - BP2159b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EPS15 Blocking Peptide - 33R-4868 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Recombinant Human Epidermal growth factor receptor substrate 15(EPS15) ,partial - CSB-YP007748HU CSB-EP007748HU CSB-BP007748HU CSB-MP007748HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Eps15 (1-896) - sc-4235 WB from Santa Cruz Biotechnology Category Protein Prices $88.00 Sizes 10 µg/0.1 ml Species Human

AF1P / EPS15 - TP312097 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

EPS15 Recombinant Protein Antigen - NBP1-89221PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

EPS15-Antibody-N-term-Blocking-Peptide - BP2159a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

EPS15 Peptide, Human - M34GP05012H from Creative Peptides Category Peptide Source Synthetic. Species Human

Epidermal growth factor receptor substrate 15 (EPS15), partial, Recombinant Protein - MBS962635 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Search more