| Gene Symbol | EPS15 |
|---|---|
| Entrez Gene | 2060 |
| Alt Symbol | AF-1P, AF1P, MLLT5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | epidermal growth factor receptor pathway substrate 15 |
| Other Description | ALL1 fused gene from chromosome 1|epidermal growth factor receptor substrate 15|protein AF-1p |
| Swissprots | P42566 D3DPJ2 B2R8J7 Q5SRH4 |
| Accessions | CAR81473 CAS91489 EAX06822 EAX06823 EAX06824 P42566 AA789139 AF052132 AF331760 AK090936 BAG52249 AK129853 AK294297 BAH11726 AK308128 AK313396 BAG36194 AW949896 BC054006 AAH54006 BM681433 BX647676 CD657119 DA801048 DQ367924 ABD34786 U07707 AAA52101 Z29064 CAA82305 Z29070 XM_005270618 XP_005270675 XM_006710446 XP_006710509 XM_011540991 XP_011539293 NM_001159969 NP_001153441 NM_001981 NP_001972 |
| Function | Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2. {ECO:0000269|PubMed:16903783, ECO:0000269|PubMed:18362181, ECO:0000269|PubMed:19458185, ECO:0000269|PubMed:22648170}. |
| Subcellular Location | Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Membrane, clathrin-coated pit. Note=Recruited to the plasma membrane upon EGFR activation and localizes to coated pits. |
| Tissue Specificity | Ubiquitously expressed. |
| Top Pathways | Endocytosis |