Rel

Gene Symbol	Rel
Entrez Gene	19696
Alt Symbol	c-Rel
Species	Mouse
Gene Type	protein-coding
Description	reticuloendotheliosis oncogene
Other Description	C-Rel proto-oncogene protein|proto-oncogene c-Rel
Swissprots	P15307
Accessions	EDL07897 P15307 AK031627 BC139447 AAI39448 BC139448 AAI39449 BC139770 AAI39771 X15842 CAA33843 X60271 CAA42817 NM_009044 NP_033070
Function	Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF- kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an in
Subcellular Location	Nucleus.
Top Pathways	Viral carcinogenesis, Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics

SignalSilence ® c-Rel siRNA I (Mouse Specific) - 13058 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

SignalSilence ® c-Rel siRNA II (Mouse Specific) - 13170 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

c-Rel CRISPR/Cas9 KO Plasmid (m) - sc-422641 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel HDR Plasmid (m) - sc-422641-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel Double Nickase Plasmid (m) - sc-422641-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel Double Nickase Plasmid (m2) - sc-422641-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel CRISPR Activation Plasmid (m) - sc-422641-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel CRISPR Activation Plasmid (m2) - sc-422641-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel Lentiviral Activation Particles (m) - sc-422641-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel Lentiviral Activation Particles (m2) - sc-422641-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Mouse

c-Rel siRNA (m) - sc-29858 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

c-Rel shRNA Plasmid (m) - sc-29858-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

c-Rel shRNA (m) Lentiviral Particles - sc-29858-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Mouse

MISSION® esiRNA - EMU072641 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN40071 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND40071 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

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