| Gene Symbol |
SH3PXD2B
|
| Entrez Gene |
285590
|
| Alt Symbol |
FAD49, FTHS, HOFI, KIAA1295, TKS4, TSK4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
SH3 and PX domains 2B
|
| Other Description |
SH3 and PX domain-containing protein 2B|adapter protein HOFI|adaptor protein HOFI|factor for adipocyte differentiation 49|tyrosine kinase substrate with four SH3 domains
|
| Swissprots |
A1X283 Q9P2Q1 B6F0V2
|
| Accessions |
A1X283 EAW61431 EAW61432 EAW61433 EAW61434 EAW61435 AB037716 BAA92533 AB430862 BAG81977 AK000838 BAA91395 AK095834 AK128871 BC016513 BC038561 BC065230 BC110316 BC156242 AAI56243 BC157116 AAI57117 CA308160 DQ109556 AAZ99795 XM_005265888 XP_005265945 NM_001017995 NP_001017995 NM_001308175 NP_001295104
|
| Function |
Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in fibroblasts. {ECO:0000269|PubMed:20137777}.
|