SH3PXD2B

Gene Symbol SH3PXD2B
Entrez Gene 285590
Alt Symbol FAD49, FTHS, HOFI, KIAA1295, TKS4, TSK4
Species Human
Gene Type protein-coding
Description SH3 and PX domains 2B
Other Description SH3 and PX domain-containing protein 2B|adapter protein HOFI|adaptor protein HOFI|factor for adipocyte differentiation 49|tyrosine kinase substrate with four SH3 domains
Swissprots A1X283 Q9P2Q1 B6F0V2
Accessions A1X283 EAW61431 EAW61432 EAW61433 EAW61434 EAW61435 AB037716 BAA92533 AB430862 BAG81977 AK000838 BAA91395 AK095834 AK128871 BC016513 BC038561 BC065230 BC110316 BC156242 AAI56243 BC157116 AAI57117 CA308160 DQ109556 AAZ99795 XM_005265888 XP_005265945 NM_001017995 NP_001017995 NM_001308175 NP_001295104
Function Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. {ECO:0000250}.
Tissue Specificity Expressed in fibroblasts. {ECO:0000269|PubMed:20137777}.

SH3PXD2B CRISPR/Cas9 KO Plasmid (h) - sc-409407 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B HDR Plasmid (h) - sc-409407-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B Double Nickase Plasmid (h) - sc-409407-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B Double Nickase Plasmid (h2) - sc-409407-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B CRISPR Activation Plasmid (h) - sc-409407-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B CRISPR Activation Plasmid (h2) - sc-409407-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B Lentiviral Activation Particles (h) - sc-409407-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B Lentiviral Activation Particles (h2) - sc-409407-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

SH3PXD2B siRNA (h) - sc-91980 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SH3PXD2B shRNA Plasmid (h) - sc-91980-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SH3PXD2B shRNA (h) Lentiviral Particles - sc-91980-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN19277 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19277 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

SH3PXD2B siRNA (Human) - CRJ7110 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SH3PXD2B - MBS8225207 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SH3PXD2B (NM_001017995.2) - SHH406824 from Creative biogene

Category siRNA
Species Reactivities Human

Human SH3PXD2B siRNA - orb277611 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SH3PXD2B shRNA Plasmid (Human) - CHJ7110 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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