SH3PXD2B

Gene Symbol SH3PXD2B
Entrez Gene 285590
Alt Symbol FAD49, FTHS, HOFI, KIAA1295, TKS4, TSK4
Species Human
Gene Type protein-coding
Description SH3 and PX domains 2B
Other Description SH3 and PX domain-containing protein 2B|adapter protein HOFI|adaptor protein HOFI|factor for adipocyte differentiation 49|tyrosine kinase substrate with four SH3 domains
Swissprots A1X283 Q9P2Q1 B6F0V2
Accessions A1X283 EAW61431 EAW61432 EAW61433 EAW61434 EAW61435 AB037716 BAA92533 AB430862 BAG81977 AK000838 BAA91395 AK095834 AK128871 BC016513 BC038561 BC065230 BC110316 BC156242 AAI56243 BC157116 AAI57117 CA308160 DQ109556 AAZ99795 XM_005265888 XP_005265945 NM_001017995 NP_001017995 NM_001308175 NP_001295104
Function Adapter protein involved in invadopodia and podosome formation and extracellular matrix degradation. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. Plays a role in mitotic clonal expansion during the immediate early stage of adipocyte differentiation (By similarity). {ECO:0000250}.
Subcellular Location Cytoplasm {ECO:0000250}. Cell projection, podosome {ECO:0000250}. Note=Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells. {ECO:0000250}.
Tissue Specificity Expressed in fibroblasts. {ECO:0000269|PubMed:20137777}.

SH3PXD2B (T-13) - sc-136857 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

SH3PXD2B (D-12) - sc-136855 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-SH3PXD2B antibody - ab122342 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122342, at a 1/200 dilution, staining SH3PXD2B in paraffin-embedded Human pancreas tissue by immunohistochemistry.

Anti-SH3PXD2B antibody - ab123503 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Detection of Human SH3PXD2B by Immunoprecipitation from HeLa whole cell lysate (1 mg for IP, 20% of IP loaded), using ab123503 at 6 µg/mg lysate for IPSubsequent Western blot detection used an antibody which recognized a downstream epitope of SH3PXD2B. Detection: Chemiluminescence with an exposure time of 10 seconds.

Anti-SH3PXD2B Antibody (aa257-477) - LS-C126276 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2B Antibody (aa431-595) - LS-C126277 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2B Antibody (aa300-350) - LS-C290107 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2B Antibody (aa600-650) - LS-C290113 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

SH3PXD2B Antibody - NBP1-93965 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SH3PXD2B Antibody [NBP1-93965] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4

SH3PXD2B antibody - H00285590-B01P from Acris Antibodies

Prices $1,530.00
Sizes 500 µg
Host Mouse
Clonality Polyclonal

SH3PXD2B antibody - 25253-1-AP from Proteintech Group

Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2B (aa 556-642) polyclonal antibody - DPABH-20638 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-SH3PXD2B (aa 300-350) polyclonal antibody - DPABH-21531 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

TKS4 Antibody - A303-436A from Bethyl Labs

Prices $99.00, $339.00
Sizes 10 µl (1 mg/ml), 100 µl (1 mg/ml)
Host Rabbit
Clonality Polyclonal

TKS4 Antibody - A303-437A from Bethyl Labs

Prices $99.00, $229.00, $339.00
Sizes 20 µl (2 blots), 100 µl (10 blots), 100 µl (0.2 mg/ml)
Host Rabbit
Clonality Polyclonal

TKS4 Antibody AbVantage™ Pack - A311-268A from Bethyl Labs

Prices $472.00
Sizes 1 pack
Host Rabbit
Clonality Polyclonal

SH3 and PX domain-containing protein 2B, Polyclonal Antibody - MBS619883 from MyBioSource

Prices $645.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

SH3 and PX domain-containing protein 2B, Polyclonal Antibody - MBS619978 from MyBioSource

Prices $645.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-human Tks4 Antibody - 09-267 from EMD Millipore

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot Analysis:<br />Representative lot data.<br /><br />10 µg of Anti-human Tks4 was used to immunoprecipitate from 500 µg of NIH3T3 whole cell lysate The antibody was collected with Protein A beads and eluted with sample buffer. 50 µg of NIH3T3 IP cell lysate was then resolved via SDS-PAGE, transferred to PVDF and probed with 3 µg/mL of the same Anti-Tks4 polyclonal antibody. Proteins were visualized using an anti-rabbit secondary antibody conjugated to HRP that does not recognize denatured IgG. Detection using a chemiluminescence system (Cat. No. 17-373).<br /><br />Arrow indicates Tks4 (~ 130 kDa).<br />

TKS4 (431-595) antibody - AP56026PU-N from Acris Antibodies

Prices $380.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot Analysis:Representative lot data.10 µg of Anti-human Tks4 was used to immunoprecipitate from 500 µg of NIH3T3 whole cell lysate The antibody was collected with Protein A beads and eluted with sample buffer. 50 µg of NIH3T3 IP cell lysate was then resolved via SDS-PAGE, transferred to PVDF and probed with 3 µg/mL of the same Anti-Tks4 polyclonal antibody. Proteins were visualized using an anti-rabbit secondary antibody conjugated to HRP that does not recognize denatured IgG. Detection using a chemiluminescence system.Arrow indicates Tks4 (~ 130 kDa).

Anti-SH3PXD2B antibody produced in rabbit - HPA036471 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SH3PXD2B: <B>Cat. No. HPA036471</B>: Immunohistochemical staining of human pancreas shows moderate cytoplasmic positivity in exocrine glandular cells.

Anti-human Tks4 Antibody - 09-267 from Sigma-Aldrich

Prices $319.00
Sizes 09-267
Clonality Polyclonal
Western Blot Analysis:<br />Representative lot data.<br /><br />10 µg of Anti-human Tks4 was used to immunoprecipitate from 500 µg of NIH3T3 whole cell lysate The antibody was collected with Protein A beads and eluted with sample buffer. 50 µg of NIH3T3 IP cell lysate was then resolved via SDS-PAGE, transferred to PVDF and probed with 3 µg/mL of the same Anti-Tks4 polyclonal antibody. Proteins were visualized using an anti-rabbit secondary antibody conjugated to HRP that does not recognize denatured IgG. Detection using a chemiluminescence system (Cat. No. 17-373).<br /><br />Arrow indicates Tks4 (~ 130 kDa).<br />

Anti-mouse Tks4 Antibody - 09-260 from Sigma-Aldrich

Prices $319.00
Sizes 09-260
Clonality Polyclonal
Immunocytochemistry:<br />3T3-Src (Y527F) transformed cells (A) and 3T3 cells (B) were plated and fixed then stained with a 1:3000 dilution of Anti-mouse Tks4. Proteins were visualized using an anti-rabbit secondary conjugated to FITC (See Buschman, 2009 reference for further detail).<br />

SH3PXD2B-Antibody-C-Term - AP22070b from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SH3PXD2B Antibody (C-Term) at 1:2000 dilution Lane 1: U-251 MG whole cell lysate Lane 2: U-87 MG whole cell lysate Lane 3: SH-SY5Y whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 102 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

FAD49 antibody - orb317617 from Biorbyt

Prices $255.00, $340.00
Sizes 100 μg, 200 μg
Host Rabbit
Clonality Polyclonal
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