IFT57

Gene Symbol	IFT57
Entrez Gene	55081
Alt Symbol	ESRRBL1, HIPPI, MHS4R2
Species	Human
Gene Type	protein-coding
Description	intraflagellar transport 57
Other Description	HIP1 protein interactor|HIP1-interacting protein|dermal papilla-derived protein 8|estrogen-related receptor beta like 1|estrogen-related receptor beta-like protein 1|huntingtin interacting protein-1 interacting protein|intraflagellar transport 57 homolog|intraflagellar transport protein 57 homolog
Swissprots	Q96DA9 Q9NWB7
Accessions	EAW79730 Q9NWB7 AB014762 BAB87803 AF139576 AAK13588 AF245220 AAK28373 AK001009 BAA91466 AK298854 BAG60977 BC009690 AAH09690 BC011899 AAH11899 CR457251 CAG33532 DA362330 DQ893050 ABM83976 DQ896298 ABM87297 NM_018010 NP_060480
Function	Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250, ECO:0000269|PubMed:11788820, ECO:0000269|PubMed:17107665, ECO:0000269|PubMed:17623017}.
Subcellular Location	Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Concentrates within the inner segment of cilia. {ECO:0000250}.
Tissue Specificity	Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level). {ECO:0000269|PubMed:11788820}.
Top Pathways	Huntington's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HIPPI full length protein - ab162953 from Abcam Category Protein Source Wheat germ Species Human

Human HIPPI protein fragment - ab162954 from Abcam Category Protein Source Wheat germ Species Human

IFT57 / HIPPI Antibody Blocking Peptide - LS-E27037 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HIPPI Protein - H00055081-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human HIPPI Protein - H00055081-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

IFT57-Antibody-N-term-Blocking-peptide - BP12026a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

IFT57-Antibody-N-term-Blocking-Peptide - BP16420a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

HIPPI blocking peptide - GTX88435-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

HIPPI Peptide - AC21-1860-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

HIP1-interacting protein - H00055081-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

HIP1-interacting protein - H00055081-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

HIP1-interacting protein - H00055081-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

HIP1-interacting protein - H00055081-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IFT57 Peptide - 46-988P from ProSci Category Peptide Species Human, Mouse

IFT57 fusion protein - ag1566 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Intraflagellar transport protein 57 homolog(IFT57) - CSB-YP865156HU CSB-EP865156HU CSB-BP865156HU CSB-MP865156HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

IFT57 Protein - abx163836 from Abbexa Category Protein Species Human

HIP1-interacting protein - TP304116 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HIPPI, Peptide - MBS425285 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Bovine

HIPPI Recombinant Protein Antigen - NBP1-84788PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

HIPPI Recombinant Protein Antigen - NBP1-84787PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

IFT57 Peptide, Human - M34GP07468H from Creative Peptides Category Peptide Source Synthetic. Species Human

IFT57 Immunizing peptide - orb59539 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg

Intraflagellar transport protein 57 homolog (IFT57), Recombinant Protein - MBS1472857 from MyBioSource Category Protein Prices $1,205.00, $1,205.00, $1,425.00, $1,425.00, $1,945.00, $1,945.00, $2,410.00, $2,410.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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