IFT57

Gene Symbol IFT57
Entrez Gene 55081
Alt Symbol ESRRBL1, HIPPI, MHS4R2
Species Human
Gene Type protein-coding
Description intraflagellar transport 57
Other Description HIP1 protein interactor|HIP1-interacting protein|dermal papilla-derived protein 8|estrogen-related receptor beta like 1|estrogen-related receptor beta-like protein 1|huntingtin interacting protein-1 interacting protein|intraflagellar transport 57 homolog|intraflagellar transport protein 57 homolog
Swissprots Q96DA9 Q9NWB7
Accessions EAW79730 Q9NWB7 AB014762 BAB87803 AF139576 AAK13588 AF245220 AAK28373 AK001009 BAA91466 AK298854 BAG60977 BC009690 AAH09690 BC011899 AAH11899 CR457251 CAG33532 DA362330 DQ893050 ABM83976 DQ896298 ABM87297 NM_018010 NP_060480
Function Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250, ECO:0000269|PubMed:11788820, ECO:0000269|PubMed:17107665, ECO:0000269|PubMed:17623017}.
Subcellular Location Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Concentrates within the inner segment of cilia. {ECO:0000250}.
Tissue Specificity Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level). {ECO:0000269|PubMed:11788820}.
Top Pathways Huntington's disease

Hippi CRISPR/Cas9 KO Plasmid (h) - sc-412438 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi HDR Plasmid (h) - sc-412438-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi Double Nickase Plasmid (h) - sc-412438-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi Double Nickase Plasmid (h2) - sc-412438-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi CRISPR Activation Plasmid (h) - sc-412438-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi CRISPR Activation Plasmid (h2) - sc-412438-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi Lentiviral Activation Particles (h) - sc-412438-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi Lentiviral Activation Particles (h2) - sc-412438-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Hippi siRNA (h) - sc-105454 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Hippi shRNA Plasmid (h) - sc-105454-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Hippi shRNA (h) Lentiviral Particles - sc-105454-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

HIPPI RNAi - H00055081-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU045121 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN10506 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10506 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

IFT57 siRNA (Human) - CRJ0453 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IFT57 - MBS8200612 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human IFT57 (NM_018010.3) - SHH317329 from Creative biogene

Category siRNA
Species Reactivities Human

Human IFT57 siRNA - orb270954 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

IFT57 shRNA Plasmid (Human) - CHJ0453 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

IFT57 miRNA 3'UTR clone - MiUTR3H-08612 from Creative biogene

Species Reactivities Human
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