Gene Symbol | IFT57 |
---|---|
Entrez Gene | 55081 |
Alt Symbol | ESRRBL1, HIPPI, MHS4R2 |
Species | Human |
Gene Type | protein-coding |
Description | intraflagellar transport 57 |
Other Description | HIP1 protein interactor|HIP1-interacting protein|dermal papilla-derived protein 8|estrogen-related receptor beta like 1|estrogen-related receptor beta-like protein 1|huntingtin interacting protein-1 interacting protein|intraflagellar transport 57 homolog|intraflagellar transport protein 57 homolog |
Swissprots | Q96DA9 Q9NWB7 |
Accessions | EAW79730 Q9NWB7 AB014762 BAB87803 AF139576 AAK13588 AF245220 AAK28373 AK001009 BAA91466 AK298854 BAG60977 BC009690 AAH09690 BC011899 AAH11899 CR457251 CAG33532 DA362330 DQ893050 ABM83976 DQ896298 ABM87297 NM_018010 NP_060480 |
Function | Required for the formation of cilia. Plays an indirect role in sonic hedgehog signaling, cilia being required for all activity of the hedgehog pathway (By similarity). Has pro- apoptotic function via its interaction with HIP1, leading to recruit caspase-8 (CASP8) and trigger apoptosis. Has the ability to bind DNA sequence motif 5'-AAAGACATG-3' present in the promoter of caspase genes such as CASP1, CASP8 and CASP10, suggesting that it may act as a transcription regulator; however the relevance of such function remains unclear. {ECO:0000250, ECO:0000269|PubMed:11788820, ECO:0000269|PubMed:17107665, ECO:0000269|PubMed:17623017}. |
Subcellular Location | Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250}. Note=Concentrates within the inner segment of cilia. {ECO:0000250}. |
Tissue Specificity | Present in many tissues such as brain, thymus, lymph node, lung, liver, skin and kidney (at protein level). {ECO:0000269|PubMed:11788820}. |
Top Pathways | Huntington's disease |
Hippi (D-6) - sc-390120 from Santa Cruz Biotechnology
|
||||||||||
Hippi (C-16) - sc-21998 from Santa Cruz Biotechnology
|
||||||||||
Hippi (H-232) - sc-366022 from Santa Cruz Biotechnology
|
||||||||||
Hippi (JA52) - sc-130456 from Santa Cruz Biotechnology
|
||||||||||
Hippi (N-18) - sc-21995 from Santa Cruz Biotechnology
|
||||||||||
Hippi (Q-20) - sc-21997 from Santa Cruz Biotechnology
|
||||||||||
Anti-HIPPI antibody - ab5205 from Abcam
|
||||||||||
Anti-HIPPI antibody [5B6] - ab118048 from Abcam
|
||||||||||
Anti-IFT57 / HIPPI Antibody - LS-C311272 from LifeSpan Bioscience
|
||||||||||
Anti-IFT57 / HIPPI Antibody (clone 1G8) - LS-C139226 from LifeSpan Bioscience
|
||||||||||
Anti-IFT57 / HIPPI Antibody (clone 1H2) - LS-C114967 from LifeSpan Bioscience
|
||||||||||
Anti-IFT57 / HIPPI Antibody (aa103-117) IHC-plus⢠- LS-B7734 from LifeSpan Bioscience
|
||||||||||
Anti-IFT57 / HIPPI Antibody (clone 5B6) - LS-C114966 from LifeSpan Bioscience
|
||||||||||
Anti-IFT57 / HIPPI Antibody (clone 2G3) - LS-C114975 from LifeSpan Bioscience
|
||||||||||
Anti-IFT57 / HIPPI Antibody (clone 4F6) - LS-C114976 from LifeSpan Bioscience
|
||||||||||
Anti-IFT57 / HIPPI Antibody (aa214-313, Azide-free) - LS-C327660 from LifeSpan Bioscience
|
||||||||||
HIPPI Antibody (4F6) - NBP2-02313 from Novus Biologicals
|
||||||||||
HIPPI Antibody - NBP2-16835 from Novus Biologicals
|
||||||||||
HIPPI Antibody - NBP1-32932 from Novus Biologicals
|
||||||||||
HIPPI Antibody - H00055081-D01P from Novus Biologicals
|
||||||||||
HIPPI Antibody - NBP1-28913 from Novus Biologicals
|
||||||||||
HIPPI Antibody (3G4) - H00055081-M04 from Novus Biologicals
|
||||||||||
HIPPI Antibody (1G8) - H00055081-M02 from Novus Biologicals
|
||||||||||
HIPPI Antibody - H00055081-A01 from Novus Biologicals
|
||||||||||
HIPPI Polyclonal Antibody - bs-11697R from Bioss
|