CHMP5

Gene Symbol	CHMP5
Entrez Gene	51510
Alt Symbol	C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2, Vps60
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 5
Other Description	SNF7 domain containing 2|SNF7 domain-containing protein 2|apoptosis-related protein PNAS-2|chromatin modifying protein 5|chromatin-modifying protein 5|hVps60|vacuolar protein sorting-associated protein 60
Swissprots	Q9Y323 B2RD95 Q9NYS4 Q9NZZ3 Q5VXW2 Q9HB68 Q96AV2 B4DIR6
Accessions	EAW58512 EAW58513 Q9NZZ3 AF132968 AAD27743 AF161525 AAF29140 AF229832 AAF42917 AF275810 AAG23821 AI128062 AK024753 AK295744 BAG58578 AK315455 BAG37842 BC006974 AAH06974 BC007457 AAH07457 BC016698 AAH16698 BC018603 BC020796 AAH20796 BC021168 AAH21168 DQ893179 ABM84105 DQ896479 ABM87478 DQ896480 ABM87479 NM_001195536 NP_001182465 NM_016410 NP_057494
Function	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
Subcellular Location	Cytoplasm, cytosol. Endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP5 (D-11) - sc-374337 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CHMP5 (F-7) - sc-374338 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CHMP5 (H-90) - sc-67230 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

CHMP5 (Y-19) - sc-49920 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-CHMP5 antibody - ab96273 from Abcam Prices $370.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-CHMP5 antibody - ab31282 from Abcam Prices $370.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-CHMP5 antibody - C-terminal - ab174213 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CHMP5 antibody - N-terminal - ab184975 from Abcam Prices $443.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa178-204, AP) - LS-C233803 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa178-204, APC) - LS-C233804 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa178-204, Biotin) - LS-C233805 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa178-204, FITC) - LS-C233806 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa178-204, PE) - LS-C233808 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa178-204, Azide-free, HRP) - LS-C249668 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa177-204) - LS-C320359 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa202-215) - LS-C54653 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (C-Terminus) - LS-C170421 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (aa178-204) - LS-C159347 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-Vps60 / CHMP5 Antibody (clone 5C7) - LS-C340522 from LifeSpan Bioscience Prices $325.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 5C7

Anti-Vps60 / CHMP5 Antibody (aa1-202) - LS-C185830 from LifeSpan Bioscience Prices $335.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP5 Antibody - NBP1-32597 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CHMP5 Antibody - NB100-1512 from Novus Biologicals Prices $299.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-CHMP5 antibody produced in rabbit - HPA042883 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CHMP5 antibody produced in goat - SAB2500235 from Sigma-Aldrich Prices $376.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-CHMP5 antibody produced in rabbit - SAB2700334 from Sigma-Aldrich Prices $326.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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