CHMP5

Gene Symbol	CHMP5
Entrez Gene	51510
Alt Symbol	C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2, Vps60
Species	Human
Gene Type	protein-coding
Description	charged multivesicular body protein 5
Other Description	SNF7 domain containing 2|SNF7 domain-containing protein 2|apoptosis-related protein PNAS-2|chromatin modifying protein 5|chromatin-modifying protein 5|hVps60|vacuolar protein sorting-associated protein 60
Swissprots	Q9Y323 B2RD95 Q9NYS4 Q9NZZ3 Q5VXW2 Q9HB68 Q96AV2 B4DIR6
Accessions	EAW58512 EAW58513 Q9NZZ3 AF132968 AAD27743 AF161525 AAF29140 AF229832 AAF42917 AF275810 AAG23821 AI128062 AK024753 AK295744 BAG58578 AK315455 BAG37842 BC006974 AAH06974 BC007457 AAH07457 BC016698 AAH16698 BC018603 BC020796 AAH20796 BC021168 AAH21168 DQ893179 ABM84105 DQ896479 ABM87478 DQ896480 ABM87479 NM_001195536 NP_001182465 NM_016410 NP_057494
Function	Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane
Subcellular Location	Cytoplasm, cytosol. Endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
Top Pathways	Endocytosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CHMP5 peptide (202-215) - ab45718 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human CHMP5 full length protein - ab134604 from Abcam Category Protein Source E. coli Species Human

Vps60 / CHMP5 Antibody Blocking Peptide - LS-E5974 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Vps60 / CHMP5 Antibody Blocking Peptide - LS-E25858 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Vps60 / CHMP5 Antibody Blocking Peptide - LS-E23969 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CHMP5 Recombinant Protein - H00051510-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human CHMP5 Protein - NBP2-22771 from Novus Biologicals Category Protein Prices $269.00 Sizes 10 µg Source E.coli Species Human

CHMP5-Antibody-C-term-Blocking-Peptide - BP18536b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

CHMP5 blocking peptide - GTX89565-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat, Bovine

Human CHMP5 protein - orb168115 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

Human CHMP5 protein - orb246648 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

CHMP5 Immunizing peptide - orb17944 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

CHMP5 protein (His tag) - 80R-2492 from Fitzgerald Category Protein Prices $270.00 Sizes 10 µg Source E.coli

CHMP5 Peptide - AC21-0688-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CHMP5 (1-219, His-tag) - AR50564PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 50 µg Source E. coli Species Human

CHMP5 (1-219, His-tag) - AR50564PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 10 µg Source E. coli Species Human

CHMP5 - H00051510-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CHMP5 - H00051510-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CHMP5, 1-219aa, Human, His tag, E.coli - 01-P1740 from ARP American Research Products Category Protein Prices $159.00, $369.00, $849.00 Sizes 2 µg, 10 µg, 50 µg Species Human

CHMP5 Peptide - 45-399P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

CHMP5 fusion protein - ag1686 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

CHMP5, 1-219aa, Recombinant Protein - GWB-P0298L from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 10 μg, 50 μg Source E.coli Species Human

Recombinant Human CHMP5, His-tagged - CHMP5-27751TH from Creative Biomart Category Protein Source E. coli

Recombinant Human Charged Multivesicular Body Protein 5, His-tagged - CHMP5-7172H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human CHMP5, GST-tagged - CHMP5-11189H from Creative Biomart Category Protein Source E.coli Species Human

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