| Gene Symbol | CHMP5 |
|---|---|
| Entrez Gene | 51510 |
| Alt Symbol | C9orf83, CGI-34, HSPC177, PNAS-2, SNF7DC2, Vps60 |
| Species | Human |
| Gene Type | protein-coding |
| Description | charged multivesicular body protein 5 |
| Other Description | SNF7 domain containing 2|SNF7 domain-containing protein 2|apoptosis-related protein PNAS-2|chromatin modifying protein 5|chromatin-modifying protein 5|hVps60|vacuolar protein sorting-associated protein 60 |
| Swissprots | Q9Y323 B2RD95 Q9NYS4 Q9NZZ3 Q5VXW2 Q9HB68 Q96AV2 B4DIR6 |
| Accessions | EAW58512 EAW58513 Q9NZZ3 AF132968 AAD27743 AF161525 AAF29140 AF229832 AAF42917 AF275810 AAG23821 AI128062 AK024753 AK295744 BAG58578 AK315455 BAG37842 BC006974 AAH06974 BC007457 AAH07457 BC016698 AAH16698 BC018603 BC020796 AAH20796 BC021168 AAH21168 DQ893179 ABM84105 DQ896479 ABM87478 DQ896480 ABM87479 NM_001195536 NP_001182465 NM_016410 NP_057494 |
| Function | Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT- III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane |
| Subcellular Location | Cytoplasm, cytosol. Endosome membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body. |
| Top Pathways | Endocytosis |