| Gene Symbol |
KCNN4
|
| Entrez Gene |
3783
|
| Alt Symbol |
IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
|
| Other Description |
SKCa 4|SKCa4|intermediate conductance calcium-activated potassium channel protein 4|potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4|putative Gardos channel|putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel|small conductance calcium-activated potassium channel 4
|
| Swissprots |
Q53XR4 O15554
|
| Accessions |
AAG26917 CAB70490 CBM42811 EAW57229 EAW57230 O15554 AB128983 BAI52725 AB128984 BAI52726 AB128985 BAI52727 AF000972 AAB82739 AF022150 AAC23541 AF022797 AAC51913 AF033021 AAC36804 AF053403 AAC35281 AF395661 AAK81862 BC015337 AAH15337 BT007426 AAP36094 DQ891493 ABM82419 DQ894684 ABM85610 XM_005258882 XP_005258939 XM_005258883 XP_005258940 XM_011526938 XP_011525240 XR_935823 NM_002250 NP_002241
|
| Function |
Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. {ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614}.
|
| Subcellular Location |
Membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Widely expressed in non-excitable tissues.
|
| Top Pathways |
Salivary secretion, Protein digestion and absorption
|