KCNN4

Gene Symbol KCNN4
Entrez Gene 3783
Alt Symbol IK, IK1, IKCA1, KCA4, KCa3.1, SK4, hIKCa1, hKCa4, hSK4
Species Human
Gene Type protein-coding
Description potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
Other Description SKCa 4|SKCa4|intermediate conductance calcium-activated potassium channel protein 4|potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4|putative Gardos channel|putative erythrocyte intermediate conductance calcium-activated potassium Gardos channel|small conductance calcium-activated potassium channel 4
Swissprots Q53XR4 O15554
Accessions AAG26917 CAB70490 CBM42811 EAW57229 EAW57230 O15554 AB128983 BAI52725 AB128984 BAI52726 AB128985 BAI52727 AF000972 AAB82739 AF022150 AAC23541 AF022797 AAC51913 AF033021 AAC36804 AF053403 AAC35281 AF395661 AAK81862 BC015337 AAH15337 BT007426 AAP36094 DQ891493 ABM82419 DQ894684 ABM85610 XM_005258882 XP_005258939 XM_005258883 XP_005258940 XM_011526938 XP_011525240 XR_935823 NM_002250 NP_002241
Function Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. {ECO:0000269|PubMed:17157250, ECO:0000269|PubMed:18796614}.
Subcellular Location Membrane; Multi-pass membrane protein.
Tissue Specificity Widely expressed in non-excitable tissues.
Top Pathways Salivary secretion, Protein digestion and absorption

IK1 (D-5) - sc-365265 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IK1 (D-5): sc-365265. Western blot analysis of IK1 expression in HCT 116 (A), HeLa (B) and DU 145 (C) whole cell lysates.

IK1 (E-14) - sc-27081 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IK1 (E-14): sc-27081. Western blot analysis of IK1 expression in mouse stomach tissue extract.

IK1 (F-15) - sc-27080 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IK1 (F-15): sc-27080. Western blot analysis of IK1 expression in COLO 320DM (A), NRK (B) and HCT 116 (C) whole cell lysates.

IK1 (C-16) - sc-27082 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

IK1 (H-120) - sc-32949 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IK1 (H-120): sc-32949. Western blot analysis of IK1 expression in PMA treated Jurkat whole cell lysate.

Anti-KCNN4 antibody - ab110105 from Abcam

Prices $370.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 antibody - ab75956 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-KCNN4 antibody (ab75956) at 1 µg/mlLane 1 : Skin (Human) Tissue Lysate - adult normal tissue (ab30166)Lane 2 : Placenta (Human) Tissue Lysate - adult normal tissue (ab29745)Lysates/proteins at 10 µg per lane.SecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KCNN4 antibody - ab169284 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-KCNN4 antibody (ab169284) at 1 µg/mlLane 1 : KCNN4 transfected 293T lysateLane 2 : Non-transfected 293T lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-KCNN4 antibody - C-terminal - ab83740 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-KCNN4 antibody - C-terminal (ab83740) at 1/500 dilution + Liver (Human) Tissue Lysate - adult normal tissue (ab29889) at 10 µgSecondaryGoat polyclonal to Rabbit IgG - H&L - Pre-Adsorbed (HRP) at 1/3000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-KCNN4 antibody - N-terminal - ab181475 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody (aa351-364) - LS-C122428 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody (C-Terminus) - LS-C132125 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody (aa11-28, Sepharose) - LS-C171768 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody (aa11-28, Magnetic beads) - LS-C171767 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody (C-Terminus) - LS-C136679 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody - LS-C341393 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody (C-Terminus) - LS-C80110 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
HepG2 cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-KCNN4 / KCa3.1 Antibody (aa331-380) - LS-C199160 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts from HepG2 cells, using KCNN4 Antibody. The lane on the right was incubated with synthetic peptide.

Anti-KCNN4 / KCa3.1 Antibody (aa11-28) - LS-C171766 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody - LS-C335196 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human kidney using KCNN4 antibody at dilution of 1:200 (x400 lens).

Anti-KCNN4 / KCa3.1 Antibody (aa227-239) IHC-plus™ - LS-B5138 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-KCNN4 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5138 concentration 3.75 ug/ml.

Anti-KCNN4 / KCa3.1 Antibody (aa11-28) - LS-C312281 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KCNN4 / KCa3.1 Antibody (C-Terminus) IHC-plus™ - LS-A9581 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNN4 antibody LS-A9581 IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-KCNN4 / KCa3.1 Antibody (N-Terminus) IHC-plus™ - LS-A9579 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-KCNN4 antibody LS-A9579 IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

KCNN4 Antibody - NBP2-32484 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: KCNN4 Antibody [NBP2-32484] - Staining of human smooth muscle shows strong cytoplasmic positivity in smooth muscle cells.
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