NRP1

Gene Symbol	NRP1
Entrez Gene	8829
Alt Symbol	BDCA4, CD304, NP1, NRP, VEGF165R
Species	Human
Gene Type	protein-coding
Description	neuropilin 1
Other Description	neuropilin-1|transmembrane receptor|vascular endothelial cell growth factor 165 receptor
Swissprots	O14786 Q5T7F3 Q5T7F1 O60461 B0LPG9 Q86T59 Q96I90 Q96IH5 Q5T7F2
Accessions	AAG41893 AAG41894 AAG41895 AAG41896 AAP78927 ABY87548 CDM22288 EAW85942 EAW85943 EAW85944 EAW85945 O14786 AA973607 AB209641 BAD92878 AF016050 AAC12921 AF018956 AAC51759 AF086016 AF145712 AAF44344 AF268691 AAQ14300 AF280547 AAG41406 AK292822 BAF85511 AL698999 AL833608 CAH10397 AY249243 AAP80144 BC007533 AAH07533 BC007737 AAH07737 BT006995 AAP35641 BX510902 CAD91133 BX648025 CAH10373 BX648250 CR749333 CAH18187 DA702852 EU831654 ACE87254 EU831737 ACE86571 XM_006717521 XP_006717584 XM_006717522 XP_006717585 XM_006717523 XP_006717586 XM_006717524 XP_006717587 XM_006717525 XP_006717588 XM_006717526 XP_006717589 XM_011519755 XP_011518057 XM_011519756 XP_011518058 NM_001024628 NP_001019799 NM_001024629 NP_001019800 NM_001244972 NP_001231901 NM_001244973 NP_001231902 NM_003873 NP_003864 NR_045259
Function	The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Top Pathways	Axon guidance, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Neuropilin 1 protein fragment - ab184734 from Abcam Category Protein Prices $735.00 Sizes 50 µg Source HEK 293 cells Species Human

Human Neuropilin 1 full length protein - ab132179 from Abcam Category Protein Source Wheat germ Species Human

Human Neuropilin 1 peptide - ab42720 from Abcam Category Peptide Species Human

Neuropilin 1 peptide - ab189308 from Abcam Category Peptide

Rat Neuropilin 1 peptide - ab65666 from Abcam Category Peptide

NRP1-Antibody-C-term-Blocking-Peptide - BP9071b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Neuropilin-1, CF - 3870-N1-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Phe22-Lys644, with a C-terminal 6-His tag

Human Neuropilin 1 Fc tag protein - orb83086 from Biorbyt Category Protein Prices $357.00, $612.00 Sizes 20 μg, 50 μg Source Human Species Human

Cynomolgus Neuropilin-1 protein - orb139390 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Human Cells

Cynomolgus Neuropilin-1 protein - orb139391 from Biorbyt Category Protein Prices $323.00, $612.00 Sizes 20 μg, 50 μg Source Human Cells

Neuropilin 1 Blocking Peptide - 33R-10963 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

Human Neuropilin 1 Protein - abx068256 from Abbexa Category Protein Source E.coli Species Human

Human Neuropilin 1 Protein - abx068259 from Abbexa Category Protein Source E.coli Species Human

Neuropilin 1 Blocking Peptide - abx063521 from Abbexa Category Peptide Species Human, Rat, Monkey

Recombinant Human Neuropilin-1 - 230-00681-10 from RayBiotech Category Protein Prices $220.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human Neuropilin-1 - 230-00681-50 from RayBiotech Category Protein Prices $308.00 Sizes 100 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human Neuropilin-1 - 230-00681-100 from RayBiotech Category Protein Prices $1,170.00 Sizes 500 µg Source Escherichia coli (E.coli) Species Human

Neuropilin 1 (NRP1), Human - 20-6987 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Human

Neuropilin 1 (NRP1), Human - 20-6988 from ARP American Research Products Category Protein Prices $449.00 Sizes 50 µg Source E.coli Species Human

Neuropilin 1 Recombinant Protein - 96-562 from ProSci Category Protein Prices $375.00 Sizes 50 µg Source HEK293 cells Species Human

Neuropilin 1 Recombinant Protein - 96-563 from ProSci Category Protein Prices $375.00 Sizes 50 µg Source HEK293 cells Species Human

NRP1 fusion protein - ag16670 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

NRP1 fusion protein - Ag23549 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET28a Species Human

NRP1 fusion protein - Ag0931 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

NRP1 fusion protein - ag2720 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

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