NRP1

Gene Symbol NRP1
Entrez Gene 8829
Alt Symbol BDCA4, CD304, NP1, NRP, VEGF165R
Species Human
Gene Type protein-coding
Description neuropilin 1
Other Description neuropilin-1|transmembrane receptor|vascular endothelial cell growth factor 165 receptor
Swissprots O14786 Q5T7F3 Q5T7F1 O60461 B0LPG9 Q86T59 Q96I90 Q96IH5 Q5T7F2
Accessions AAG41893 AAG41894 AAG41895 AAG41896 AAP78927 ABY87548 CDM22288 EAW85942 EAW85943 EAW85944 EAW85945 O14786 AA973607 AB209641 BAD92878 AF016050 AAC12921 AF018956 AAC51759 AF086016 AF145712 AAF44344 AF268691 AAQ14300 AF280547 AAG41406 AK292822 BAF85511 AL698999 AL833608 CAH10397 AY249243 AAP80144 BC007533 AAH07533 BC007737 AAH07737 BT006995 AAP35641 BX510902 CAD91133 BX648025 CAH10373 BX648250 CR749333 CAH18187 DA702852 EU831654 ACE87254 EU831737 ACE86571 XM_006717521 XP_006717584 XM_006717522 XP_006717585 XM_006717523 XP_006717586 XM_006717524 XP_006717587 XM_006717525 XP_006717588 XM_006717526 XP_006717589 XM_011519755 XP_011518057 XM_011519756 XP_011518058 NM_001024628 NP_001019799 NM_001024629 NP_001019800 NM_001244972 NP_001231901 NM_001244973 NP_001231902 NM_003873 NP_003864 NR_045259
Function The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
Subcellular Location Cell membrane; Single-pass type I membrane protein.
Tissue Specificity The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Top Pathways Axon guidance, HTLV-I infection

neuropilin CRISPR/Cas9 KO Plasmid (h) - sc-400428 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin HDR Plasmid (h) - sc-400428-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin Double Nickase Plasmid (h) - sc-400428-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin Double Nickase Plasmid (h2) - sc-400428-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin CRISPR Activation Plasmid (h) - sc-400428-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin CRISPR Activation Plasmid (h2) - sc-400428-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin Lentiviral Activation Particles (h) - sc-400428-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin Lentiviral Activation Particles (h2) - sc-400428-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

neuropilin siRNA (h) - sc-36038 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

neuropilin shRNA Plasmid (h) - sc-36038-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

neuropilin shRNA (h) Lentiviral Particles - sc-36038-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU134551 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15520 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15520 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NRP1 siRNA (Human) - CRH5826 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Neuropilin-1 RNAi - H00008829-R11 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

NRP1 shRNA Plasmid (Human) - CHH5826 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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