NRP1

Gene Symbol	NRP1
Entrez Gene	8829
Alt Symbol	BDCA4, CD304, NP1, NRP, VEGF165R
Species	Human
Gene Type	protein-coding
Description	neuropilin 1
Other Description	neuropilin-1|transmembrane receptor|vascular endothelial cell growth factor 165 receptor
Swissprots	O14786 Q5T7F3 Q5T7F1 O60461 B0LPG9 Q86T59 Q96I90 Q96IH5 Q5T7F2
Accessions	AAG41893 AAG41894 AAG41895 AAG41896 AAP78927 ABY87548 CDM22288 EAW85942 EAW85943 EAW85944 EAW85945 O14786 AA973607 AB209641 BAD92878 AF016050 AAC12921 AF018956 AAC51759 AF086016 AF145712 AAF44344 AF268691 AAQ14300 AF280547 AAG41406 AK292822 BAF85511 AL698999 AL833608 CAH10397 AY249243 AAP80144 BC007533 AAH07533 BC007737 AAH07737 BT006995 AAP35641 BX510902 CAD91133 BX648025 CAH10373 BX648250 CR749333 CAH18187 DA702852 EU831654 ACE87254 EU831737 ACE86571 XM_006717521 XP_006717584 XM_006717522 XP_006717585 XM_006717523 XP_006717586 XM_006717524 XP_006717587 XM_006717525 XP_006717588 XM_006717526 XP_006717589 XM_011519755 XP_011518057 XM_011519756 XP_011518058 NM_001024628 NP_001019799 NM_001024629 NP_001019800 NM_001244972 NP_001231901 NM_001244973 NP_001231902 NM_003873 NP_003864 NR_045259
Function	The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF-165 isoform of VEGF and VEGF-B. Coexpression with KDR results in increased VEGF-165 binding to KDR as well as increased chemotaxis. It may regulate VEGF-induced angiogenesis.
Subcellular Location	Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	The expression of isoforms 1 and 2 does not seem to overlap. Isoform 1 is expressed by the blood vessels of different tissues. In the developing embryo it is found predominantly in the nervous system. In adult tissues, it is highly expressed in heart and placenta; moderately in lung, liver, skeletal muscle, kidney and pancreas; and low in adult brain. Isoform 2 is found in liver hepatocytes, kidney distal and proximal tubules.
Top Pathways	Axon guidance, HTLV-I infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Neuropilin-1 (D62C6) Rabbit mAb - 3725 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D62C6

neuropilin (A-12) - sc-5307 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

neuropilin (C-19) - sc-7239 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

neuropilin (H-286) - sc-5541 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-Neuropilin 1 antibody - ab25998 from Abcam Prices $400.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Neuropilin 1 antibody - ab60606 from Abcam Prices $359.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Neuropilin 1 antibody - ab135903 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-Neuropilin 1 antibody - ab101470 from Abcam Prices $370.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-Neuropilin 1 antibody - ab190598 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-Neuropilin 1 antibody (Biotin) - ab83435 from Abcam Prices $370.00 Sizes 50 µg Host Goat Clonality Polyclonal

Anti-Neuropilin 1 antibody [EPR3113] - ab81321 from Abcam Prices $403.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3113

Anti-Neuropilin 1 antibody [EPR3113] (Alexa Fluor® 647) - ab198323 from Abcam Prices $425.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR3113

Anti-NRP1 / Neuropilin 1 Antibody (clone 446921) - LS-C73281 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 446921

Anti-NRP1 / Neuropilin 1 Antibody (N-Terminus) - LS-C9231 from LifeSpan Bioscience Prices $475.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody - LS-C125996 from LifeSpan Bioscience Prices $425.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-NRP1 / Neuropilin 1 Antibody (Extracellular Domain, APC) - LS-C125997 from LifeSpan Bioscience Prices $605.00 Sizes 100 tst Host Goat Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody (Extracellular Domain, CF) - LS-C125998 from LifeSpan Bioscience Prices $605.00 Sizes 100 tst Host Goat Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody (aa22-6444, clone 446921, PerCP) - LS-C125999 from LifeSpan Bioscience Prices $575.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 446921

Anti-NRP1 / Neuropilin 1 Antibody (aa71-120) - LS-C116952 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody (Extracellular Domain, PerCP) - LS-C184857 from LifeSpan Bioscience Prices $605.00 Sizes 100 tst Host Goat Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody (Extracellular Domain, RPE) - LS-C184858 from LifeSpan Bioscience Prices $605.00 Sizes 100 tst Host Goat Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody (aa22-644, clone 446921, PE) - LS-C191416 from LifeSpan Bioscience Prices $530.00 Sizes 100 tst Host Mouse Clonality Monoclonal Clone 446921

Anti-NRP1 / Neuropilin 1 Antibody (aa729-758, AP) - LS-C264779 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody - LS-C146995 from LifeSpan Bioscience Prices $410.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NRP1 / Neuropilin 1 Antibody (clone N43-7) - LS-C179858 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rat Clonality Monoclonal Clone N43-7

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