NSMCE2

Gene Symbol NSMCE2
Entrez Gene 286053
Alt Symbol C8orf36, MMS21, NSE2, ZMIZ7
Species Human
Gene Type protein-coding
Description non-SMC element 2, MMS21 homolog (S. cerevisiae)
Other Description E3 SUMO-protein ligase NSE2|MMS21 homolog|hMMS21|methyl methanesulfonate sensitivity gene 21|non-SMC element 2 homolog|non-structural maintenance of chromosomes element 2 homolog|zinc finger, MIZ-type containing 7
Swissprots Q96MF7 Q8N549
Accessions CAC38636 EAW92083 EAW92084 Q96MF7 AA580621 AK057002 BAB71338 BC032797 AAH32797 CB217595 HQ447112 ADQ31599 XM_005250875 XP_005250932 XM_005250876 XP_005250933 XM_011516974 XP_011515276 XM_011516975 XP_011515277 NM_173685 NP_775956
Function E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repai
Subcellular Location Nucleus. Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

E3 SUMO-protein ligase NSE2 (NSMCE2), Human, ELISA Kit - CSB-EL016108HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 7 pg/ml
Range 28 pg/ml-1800 pg/ml

non-SMC element 2, MMS21 homolog (S. cerevisiae) , ELISA Kit - MBS917697 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of human NSMCE2 is typically less than 7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 28 pg/ml-1800 pg/ml.

Human E3 SUMO-protein ligase NSE2(NSMCE2) ELISA kit - CSB-EL016108HU from Cusabio

Category ELISA Kit
Sensitivity 7 pg/ml.
Range 28 pg/ml-1800 pg/ml

Human NSMCE2 ELISA Kit - E026752 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of human NSMCE2 is typically less than 7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean

anti-NSMCE2 / NSE2 antibody - ARG55719 from Arigo Biolaboratories

Category ELISA Kit

NSMCE2 ELISA Kit (Human) (OKCA01213) - OKCA01213 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 7 pg/mL
Range 28 - 1,800 pg/mL
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