NSMCE2

Gene Symbol	NSMCE2
Entrez Gene	286053
Alt Symbol	C8orf36, MMS21, NSE2, ZMIZ7
Species	Human
Gene Type	protein-coding
Description	non-SMC element 2, MMS21 homolog (S. cerevisiae)
Other Description	E3 SUMO-protein ligase NSE2|MMS21 homolog|hMMS21|methyl methanesulfonate sensitivity gene 21|non-SMC element 2 homolog|non-structural maintenance of chromosomes element 2 homolog|zinc finger, MIZ-type containing 7
Swissprots	Q96MF7 Q8N549
Accessions	CAC38636 EAW92083 EAW92084 Q96MF7 AA580621 AK057002 BAB71338 BC032797 AAH32797 CB217595 HQ447112 ADQ31599 XM_005250875 XP_005250932 XM_005250876 XP_005250933 XM_011516974 XP_011515276 XM_011516975 XP_011515277 NM_173685 NP_775956
Function	E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repai
Subcellular Location	Nucleus. Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NSE2 full length protein - ab132298 from Abcam Category Protein Source Wheat germ Species Human

NSE2 peptide - ab94387 from Abcam Category Peptide

MMS21 / NSMCE2 Antibody Blocking Peptide - LS-E30929 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MMS21 / NSMCE2 Antibody Blocking Peptide - LS-E20136 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Nse2 Protein - H00286053-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Nse2 Blocking Peptide - NBP1-76263PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

NSMCE2 Blocking Peptide - 33R-4372 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NSMCE2 - H00286053-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

NSMCE2 - H00286053-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

NSMCE2 control peptide - AP26209CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

MMS21 Peptide - 5759P from ProSci Category Peptide Species Human

NSMCE2 fusion protein - Ag4545 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human NSMCE2, GST-tagged - NSMCE2-1375H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human E3 SUMO-protein ligase NSE2(NSMCE2) - CSB-YP836260HU CSB-EP836260HU CSB-BP836260HU CSB-MP836260HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

NSMCE2 (full length, N-term HIS tag) - TP760839 from Acris Antibodies Category Protein Prices $199.00 Sizes 50 µg Source E. coli Species Human

Nse2 Recombinant Protein Antigen - NBP2-49459PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

NSMCE2 Peptide, Human - M34GP10649H from Creative Peptides Category Peptide Source Synthetic. Species Human

E3 SUMO-protein ligase NSE2 (NSMCE2), Recombinant Protein - MBS1446528 from MyBioSource Category Protein Prices $995.00, $995.00, $1,225.00, $1,225.00, $1,525.00, $1,525.00, $1,990.00, $1,990.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Nse2 Recombinant Protein Antigen - NBP2-58712PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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