NSMCE2

Gene Symbol NSMCE2
Entrez Gene 286053
Alt Symbol C8orf36, MMS21, NSE2, ZMIZ7
Species Human
Gene Type protein-coding
Description non-SMC element 2, MMS21 homolog (S. cerevisiae)
Other Description E3 SUMO-protein ligase NSE2|MMS21 homolog|hMMS21|methyl methanesulfonate sensitivity gene 21|non-SMC element 2 homolog|non-structural maintenance of chromosomes element 2 homolog|zinc finger, MIZ-type containing 7
Swissprots Q96MF7 Q8N549
Accessions CAC38636 EAW92083 EAW92084 Q96MF7 AA580621 AK057002 BAB71338 BC032797 AAH32797 CB217595 HQ447112 ADQ31599 XM_005250875 XP_005250932 XM_005250876 XP_005250933 XM_011516974 XP_011515276 XM_011516975 XP_011515277 NM_173685 NP_775956
Function E3 SUMO-protein ligase component of the SMC5-SMC6 complex, a complex involved in DNA double-strand break repair by homologous recombination. Is not be required for the stability of the complex. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). Acts as a E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2. Required for recruitment of telomeres to PML nuclear bodies. SUMO protein-ligase activity is required for the prevention of DNA damage-induced apoptosis by facilitating DNA repai
Subcellular Location Nucleus. Chromosome, telomere. Note=Localizes to PML nuclear bodies in ALT cell lines.

NSE2 (N-12) - sc-87338 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
NSE2 (N-12): sc-87338. Western blot analysis of NSE2 expression in human spleen tissue extract.

NSE2 (S-16) - sc-87339 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NSE2 antibody - ab105363 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-NSE2 antibody (ab105363) at 0.5 µg/mlLane 2 : Anti-NSE2 antibody (ab105363) at 1 µg/mlLane 1 : 293 cell lysateLane 2 : 293 cell lysateLysates/proteins at 15 µg per lane.

Anti-NSE2 antibody - ab71976 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-NSE2 antibody (ab71976) at 1/500 dilutionLane 1 : NSE2 transfected 293T cell lysateLane 2 : Non transfected 293T cell lysateLysates/proteins at 25 µg per lane.SecondaryGoat anti-mouse IgG (H&L)-HRP conjugate at 1/2500 dilution

Anti-NSE2 antibody [4A2] - ab119074 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4A2
All lanes : Anti-NSE2 antibody [4A2] (ab119074) at 1/500 dilutionLane 1 : HEK293T cells transfected with pCMV6-ENTRY controlLane 2 : HEK293T cells transfected with pCMV6-ENTRY NSE2Lysates/proteins at 5 µg per lane.

Anti-MMS21 / NSMCE2 Antibody (aa1-50) - LS-C290769 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MMS21 / NSMCE2 Antibody (aa50-100) - LS-C290770 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MMS21 / NSMCE2 Antibody (aa125-175) - LS-C290772 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MMS21 / NSMCE2 Antibody (aa197-247) - LS-C290773 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MMS21 / NSMCE2 Antibody - LS-C306664 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-MMS21 / NSMCE2 Antibody (C-Terminus) - LS-C115838 from LifeSpan Bioscience

Prices $325.00, $890.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of MMS21 in 293 cell lysate with MMS21 antibody at (A) 0.5 and (B) 1 ug/ml.

Anti-MMS21 / NSMCE2 Antibody (clone 4A2) - LS-C115574 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4A2
Anti-NSMCE2 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY NSMCE2.

Anti-MMS21 / NSMCE2 Antibody (clone 3C10) - LS-C115575 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C10
Anti-NSMCE2 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY NSMCE2.

Anti-MMS21 / NSMCE2 Antibody (clone 4H9) - LS-C115576 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4H9
Anti-NSMCE2 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY NSMCE2.

Anti-MMS21 / NSMCE2 Antibody (clone 6A6) - LS-C115577 from LifeSpan Bioscience

Prices $350.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6A6
Anti-NSMCE2 mouse monoclonal antibody immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY NSMCE2.

Anti-MMS21 / NSMCE2 Antibody (aa107-156) IHC-plus™ - LS-B11627 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

Nse2 Antibody - NBP1-76263 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Nse2 Antibody - H00286053-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: Nse2 Antibody [H00286053-B01] - analysis of C8orf36 expression in transfected 293T cell line by C8orf36 MaxPab polyclonal antibody (B01). Lane 1: C8orf36 transfected lysate (27.90 KDa). Lane 2: Non-transfected lysate.

Nse2 Antibody - NBP1-56293 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal

Nse2 Antibody - H00286053-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

MMS21 Polyclonal Antibody - bs-9544R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-NSMCE2 antibody produced in rabbit - SAB2103989 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-NSMCE2, antibody produced in rabbit: <B>Cat. No. SAB2103989</B>: Immunoblotting analysis of NSMCE2 in MCF7 cell lysate with NSMCE2 anitbody at 1 μg/mL.

Anti-MMS21 antibody produced in rabbit - SAB3500490 from Sigma-Aldrich

Prices $347.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-MMS21: <B>Cat. No. SAB3500490</B>: MMS21 in 293 cell lysate with MMS21 antibody at (A) 0.5 and (B) 1 μg/mL.

Anti-C8orf36 antibody produced in mouse - SAB1402088 from Sigma-Aldrich

Prices $347.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Polyclonal Anti-C8orf36, antibody produced in mouse, purified immunoglobulin: <B>Cat. No. SAB1402088</B>: Antibody concentration: 10 μg/mL using HeLa cell.

Anti-NSMCE2 (111-125) antibody produced in rabbit - SAB1103506 from Sigma-Aldrich

Prices $298.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Lysate of HEK-293T cells overexpressing human NSMCE2 was separated on SDS-PAGE, blotted with Anti-NSMCE2 (111-125) (<B>Cat. No.SAB1103506</B>) and developed using Goat Anti-Rabbit IgG-Peroxidase (<B>Cat. No. A0545</B>) and a chemiluminescent substrate.<BR/><B>Lanes</B><BR/>1. Antibody dilution 1:1,000<BR/>2. Antibody dilution 1:1,000 + NSMCE2 immunizing peptide (human, 111-125)
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