Gene Symbol | Txnrd2 |
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Entrez Gene | 26462 |
Alt Symbol | AA118373, ESTM573010, TGR, Tr3, Trxr2, Trxrd2 |
Species | Mouse |
Gene Type | protein-coding |
Description | thioredoxin reductase 2 |
Other Description | TR beta|thioredoxin reductase 2, mitochondrial|thioredoxin reductase TR3 |
Swissprots | Q91YX4 Q9JMH5 Q9JHA7 Q80VZ4 Q6KG49 Q9JLT4 |
Accessions | AAL90457 EDK97524 EDK97525 EDK97526 Q9JLT4 AB027566 BAA86986 AF136399 AAF03359 AF171053 AAD51323 AF412308 AAQ03230 AK008004 BAB25403 AK075828 AK181417 AK186982 AK188250 BC013688 AAH13688 BC029344 BC052157 AAH52157 BC052758 BF465261 NM_013711 NP_038739 |
Function | Maintains thioredoxin in a reduced state. Implicated in the defenses against oxidative stress. May play a role in redox- regulated cell signaling. |
Subcellular Location | Mitochondrion {ECO:0000269|PubMed:10721726}. |
Tissue Specificity | Expressed in liver, heart, testis and kidney. {ECO:0000269|PubMed:10455115, ECO:0000269|PubMed:10500251, ECO:0000269|PubMed:10721726}. |
Top Pathways | Selenocompound metabolism, Pyrimidine metabolism |
TrxR2 CRISPR/Cas9 KO Plasmid (m) - sc-424086 from Santa Cruz Biotechnology
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TrxR2 HDR Plasmid (m) - sc-424086-HDR from Santa Cruz Biotechnology
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TrxR2 Double Nickase Plasmid (m) - sc-424086-NIC from Santa Cruz Biotechnology
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TrxR2 Double Nickase Plasmid (m2) - sc-424086-NIC-2 from Santa Cruz Biotechnology
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TrxR2 CRISPR Activation Plasmid (m) - sc-424086-ACT from Santa Cruz Biotechnology
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TrxR2 CRISPR Activation Plasmid (m2) - sc-424086-ACT-2 from Santa Cruz Biotechnology
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TrxR2 Lentiviral Activation Particles (m) - sc-424086-LAC from Santa Cruz Biotechnology
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TrxR2 Lentiviral Activation Particles (m2) - sc-424086-LAC-2 from Santa Cruz Biotechnology
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TrxR2 siRNA (m) - sc-45820 from Santa Cruz Biotechnology
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TrxR2 shRNA Plasmid (m) - sc-45820-SH from Santa Cruz Biotechnology
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TrxR2 shRNA (m) Lentiviral Particles - sc-45820-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU067221 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN43760 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND43760 from Sigma-Aldrich
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TXNRD2 siRNA (Mouse) - CRM4761 from Cohesion Biosciences
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TXNRD2 - MBS8205494 from MyBioSource
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shRNA set against Mouse TXNRD2 (NM_013711.3) - SHH438388 from Creative biogene
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shRNA set against Mouse Txnrd2(NM_013711.3) - SHL108530 from Creative biogene
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Mouse TXNRD2 siRNA - orb284237 from Biorbyt
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TXNRD2 shRNA Plasmid (Mouse) - CHM4761 from Cohesion Biosciences
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TXNRD2 miRNA 3'UTR clone - MiUTR1M-12353 from Creative biogene
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