Gene Symbol | U2AF1 |
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Entrez Gene | 7307 |
Alt Symbol | FP793, RN, RNU2AF1, U2AF35, U2AFBP |
Species | Human |
Gene Type | protein-coding |
Description | U2 small nuclear RNA auxiliary factor 1 |
Other Description | U2 small nuclear RNA auxillary factor 1|U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit|U2 snRNP auxiliary factor small subunit|U2(RNU2) small nuclear RNA auxiliary factor binding protein|splicing factor U2AF 35 kDa subunit|splicing factor U2AF 35kDa subunit |
Swissprots | Q01081 Q71RF1 Q701P4 |
Accessions | BAA95534 EAX09501 EAX09502 EAX09503 EAX09504 EAX09505 EAX09506 Q01081 AB451244 BAG70058 AF370386 AAQ15222 AJ627978 CAF29556 AK022152 AK023589 AK094435 AK098266 AK307560 AL832665 CAH10401 BC001177 AAH01177 BC001923 AAH01923 BC005915 AAH05915 BC013786 BC032521 CB110007 HQ447764 ADQ32249 M96982 AAA36619 XM_011529743 XP_011528045 NM_001025203 NP_001020374 NM_001025204 NP_001020375 NM_006758 NP_006749 |
Function | Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:8647433}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:15096518}. Nucleus speckle {ECO:0000269|PubMed:15096518}. |
Top Pathways | Spliceosome |
Human U2AF35 full length protein - ab152778 from Abcam
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Human U2AF35 full length protein - ab156324 from Abcam
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U2AF1 Antibody Blocking Peptide - LS-E14692 from LifeSpan Bioscience
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U2AF1 Antibody Blocking Peptide - LS-E7110 from LifeSpan Bioscience
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U2AF1 Antibody Blocking Peptide - LS-E7111 from LifeSpan Bioscience
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Recombinant Human U2AF35 Protein - H00007307-P01 from Novus Biologicals
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U2AF35 Partial Recombinant Protein - H00007307-Q01 from Novus Biologicals
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U2AF1-Antibody-Center-Y114-Blocking-Peptide - BP2802d from Abgent, a WuXi AppTec company
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U2AF1-Antibody-Center-S70-Blocking-Peptide - BP2802c from Abgent, a WuXi AppTec company
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Human U2AF1 protein - orb191367 from Biorbyt
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U2AF1 Blocking Peptide - 33R-5649 from Fitzgerald
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U2AF1 protein (His tag) - 80R-2800 from Fitzgerald
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U2AF1 / U2AF35 (1-240, His-tag) - AR50919PU-N from Acris Antibodies
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U2AF1 / U2AF35 (1-240, His-tag) - AR50919PU-S from Acris Antibodies
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U2AF1 / U2AF35 - H00007307-P01 from Acris Antibodies
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U2AF1 / U2AF35 - H00007307-Q01-10 from Acris Antibodies
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U2AF1 / U2AF35 - H00007307-Q01-25 from Acris Antibodies
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U2AF1, 1-240aa, Human, His tag, E.coli - 01-P2095 from ARP American Research Products
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U2AF35 fusion protein - ag0399 from Proteintech Group
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Recombinant Human U2 small nuclear RNA auxiliary factor 1, His-tagged - U2AF1-580H from Creative Biomart
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u2AF1, 1-240aa, Human, His tag, E.coli (Denatured) - ATGP2095 from ATGen
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U2 Small Nuclear RNA Auxiliary Factor 1 Protein (Recombinant) - abx261068 from Abbexa
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U2AF35 Protein - NBP1-92553PEP from Novus Biologicals
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U2AF1 Peptide, Human - M34GP16922H from Creative Peptides
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u2AF1 - PAT-82094-1 from Nordic BioSite
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