U2AF1
| Gene Symbol | U2AF1 |
|---|---|
| Entrez Gene | 7307 |
| Alt Symbol | FP793, RN, RNU2AF1, U2AF35, U2AFBP |
| Species | Human |
| Gene Type | protein-coding |
| Description | U2 small nuclear RNA auxiliary factor 1 |
| Other Description | U2 small nuclear RNA auxillary factor 1|U2 small nuclear ribonucleoprotein auxillary factor, 35-KD subunit|U2 snRNP auxiliary factor small subunit|U2(RNU2) small nuclear RNA auxiliary factor binding protein|splicing factor U2AF 35 kDa subunit|splicing factor U2AF 35kDa subunit |
| Swissprots | Q01081 Q71RF1 Q701P4 |
| Accessions | BAA95534 EAX09501 EAX09502 EAX09503 EAX09504 EAX09505 EAX09506 Q01081 AB451244 BAG70058 AF370386 AAQ15222 AJ627978 CAF29556 AK022152 AK023589 AK094435 AK098266 AK307560 AL832665 CAH10401 BC001177 AAH01177 BC001923 AAH01923 BC005915 AAH05915 BC013786 BC032521 CB110007 HQ447764 ADQ32249 M96982 AAA36619 XM_011529743 XP_011528045 NM_001025203 NP_001020374 NM_001025204 NP_001020375 NM_006758 NP_006749 |
| Function | Plays a critical role in both constitutive and enhancer- dependent splicing by mediating protein-protein interactions and protein-RNA interactions required for accurate 3'-splice site selection. Recruits U2 snRNP to the branch point. Directly mediates interactions between U2AF2 and proteins bound to the enhancers and thus may function as a bridge between U2AF2 and the enhancer complex to recruit it to the adjacent intron. {ECO:0000269|PubMed:8647433}. |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:15096518}. Nucleus speckle {ECO:0000269|PubMed:15096518}. |
| Top Pathways | Spliceosome |
U2AF35 CRISPR/Cas9 KO Plasmid (h) - sc-404986 from Santa Cruz Biotechnology
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U2AF35 HDR Plasmid (h) - sc-404986-HDR from Santa Cruz Biotechnology
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U2AF35 Double Nickase Plasmid (h) - sc-404986-NIC from Santa Cruz Biotechnology
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U2AF35 Double Nickase Plasmid (h2) - sc-404986-NIC-2 from Santa Cruz Biotechnology
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U2AF35 CRISPR Activation Plasmid (h) - sc-404986-ACT from Santa Cruz Biotechnology
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U2AF35 CRISPR Activation Plasmid (h2) - sc-404986-ACT-2 from Santa Cruz Biotechnology
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U2AF35 Lentiviral Activation Particles (h) - sc-404986-LAC from Santa Cruz Biotechnology
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U2AF35 Lentiviral Activation Particles (h2) - sc-404986-LAC-2 from Santa Cruz Biotechnology
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U2AF35 siRNA (h) - sc-37665 from Santa Cruz Biotechnology
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U2AF35 shRNA Plasmid (h) - sc-37665-SH from Santa Cruz Biotechnology
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U2AF35 shRNA (h) Lentiviral Particles - sc-37665-V from Santa Cruz Biotechnology
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U2AF35 RNAi - H00007307-R02 from Novus Biologicals
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U2AF35 RNAi - H00007307-R03 from Novus Biologicals
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MISSION® esiRNA - EHU110481 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN22329 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22329 from Sigma-Aldrich
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U2AF1 siRNA (Human) - CRH4997 from Cohesion Biosciences
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U2AF35 RNAi - H00007307-R01 from Novus Biologicals
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U2AF1 - MBS8204657 from MyBioSource
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shRNA set against Human U2AF1 (NM_006758.2) - SHH438552 from Creative biogene
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shRNA set against Human U2AF1(NM_006758.2) - SHL109182 from Creative biogene
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shRNA set against Human U2AF1(NM_001025204.1) - SHL109218 from Creative biogene
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shRNA set against Human U2AF1(NM_001025203.1) - SHL109296 from Creative biogene
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U2AF1 shRNA Plasmid (Human) - CHH4997 from Cohesion Biosciences
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U2AF1 miRNA 3'UTR clone - MiUTR1H-10912 from Creative biogene
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